Results 171 to 180 of about 2,002 (201)
Introduction: Optogenetics and Photopharmacology [PDF]
Chemical Reviews, 2018 Wolfgang Gärtner, Dirk Trauner
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In vivo photopharmacology with light-activated opioid drugs
Neuron, 2023 Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult to interface with recordings of neural activity. Here, we demonstrate the feasibility and experimental advantages of in vivo photopharmacology using "caged" opioid drugs that are activated in the brain with light after systemic administration in an ...
Shannan McClain, Xiang, Caroline Johnson
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Photopharmacology and photoresponsive drug delivery
Chemical Society ReviewsThis review outlines the applications of photopharmacology and photoresponsive drug delivery in controlling biological activities using light for diverse biomedical applications.
Yuwei Liu, Tianyi Wang, Weiping Wang
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Chemical Reviews, 2018
Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have ...
Katharina Hüll +2 more
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Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have ...
Katharina Hüll +2 more
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Photopharmacological control of lipid function
2020Photopharmacology enables the optical control of biological processes through the use of molecular photoswitches, such as functionalized azobenzenes. In this protocol, we describe general considerations for working with bioactive azobenzene photoswitches. Our approach is exemplified with a photoswitchable sphingosine-1-phosphate analog (PhotoS1P).
Johannes, Morstein, Dirk, Trauner
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Specificity and Speed: Tethered Photopharmacology
Biochemistry, 2017Genetics and pharmacology are often seen as two distinct approaches to interrogating, elucidating, and manipulating biological systems. The former is renowned for its precision whereas the latter for its fast kinetics, reversibility, and practicality.
Philipp Leippe +2 more
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A Roadmap to Success in Photopharmacology
Accounts of Chemical Research, 2015Light is a fascinating phenomenon that ties together physics, chemistry, and biology. It is unmatched in its ability to confer information with temporal and spatial precision and has been used to map objects on the scale of tens of nanometers (10(-8) m) to light years (10(16) m).
Johannes, Broichhagen +2 more
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Photopharmacology in Alzheimer's Disease
Advanced Therapeutics, 2018AbstractIn this report, the advances of photopharmacology as a method that allows the study of therapeutically relevant target proteins for Alzheimer's disease (AD) with high spatiotemporal resolution through photoswitchable molecules that are manipulated by light irradiation will be presented.
Diego Alejandro Rodríguez‐Soacha +1 more
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Photopharmacological approaches for dissecting potassium channel physiology
Current Opinion in Pharmacology, 2022Photopharmacology allows for the remote control of ion channels and receptors by the application of light-sensitive compounds. Upon irradiation with light these molecules change their configuration, enabling channel modulation with both spatial and temporal resolution.
Stephanie Häfner, Guillaume Sandoz
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Photopharmacological control of cell signaling with photoswitchable lipids
Current Opinion in Pharmacology, 2022Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their biological applications.
Tufan K, Mukhopadhyay +2 more
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