Results 11 to 20 of about 90,516 (199)
Deletion of prominin-1 in mice results in disrupted photoreceptor outer segment protein homeostasis [PDF]
International Journal of Ophthalmology, 2021 AIM: To illustrate the underlying mechanism how prominin-1 (also known as Prom1) mutation contribute to progressive photoreceptor degeneration. METHODS: A CRISPR-mediated Prom1 knockout (Prom1-KO) mice model in the C57BL/6 was generated and the ...
Yu-Shu Xiao +12 more
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The Usher syndrome 1C protein harmonin regulates canonical Wnt signaling
Frontiers in Cell and Developmental Biology, 2023 Human Usher syndrome (USH) is the most common form of hereditary combined deaf-blindness. USH is a complex genetic disorder, and the pathomechanisms underlying the disease are far from being understood, especially in the eye and retina.
Jessica Schäfer +8 more
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Journal of Fungi, 2023 Light is an important modulating signal in fungi. Fusarium species stand out as research models for their phytopathogenic activity and their complex secondary metabolism. This includes the synthesis of carotenoids, whose induction by light is their best known photoregulated process.
Javier Pardo-Medina +2 more
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Journal of Translational Medicine, 2023 Background Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photoreceptor degeneration are currently
Daijin Li +9 more
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Photoreceptor engineering [PDF]
Frontiers in Molecular Biosciences, 2015 Sensory photoreceptors not only control diverse adaptive responses in Nature, but as light-regulated actuators they also provide the foundation for optogenetics, the non-invasive and spatiotemporally precise manipulation of cellular events by light.
Thea eZiegler +3 more
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Eye, 1998 Photoreceptor cell death is the final, irreversible event in many blinding diseases including retinitis pigmentosa, age-related macular disease and retinal detachment. This paper examines the potential strategies for preventing photoreceptor cell death in the context of current understanding of the mechanisms of cell death. There is evidence to suggest
P J, Luthert, N H, Chong
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Cells, 2020 Photoreceptor disease results in irreparable vision loss and blindness, which has a dramatic impact on quality of life. Pathogenic mutations in RP1L1 lead to photoreceptor degenerations such as occult macular dystrophy and retinitis pigmentosa.
Nicole C. L. Noel +4 more
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Plant Cryptochromes Illuminated: A Spectroscopic Perspective on the Mechanism
Frontiers in Chemistry, 2021 Plant cryptochromes are central blue light receptors for the control of land plant and algal development including the circadian clock and the cell cycle.
Lukas Goett-Zink +2 more
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Modeling inducible neuropathologies of the retina with differential phenotypes in organoids
Frontiers in Cellular Neuroscience, 2023 Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research.
Manuela Völkner +14 more
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Plant Flavoprotein Photoreceptors [PDF]
Plant and Cell Physiology, 2014 Plants depend on the surrounding light environment to direct their growth. Blue light (300-500 nm) in particular acts to promote a wide variety of photomorphogenic responses including seedling establishment, phototropism and circadian clock regulation.
Christie, John M. +3 more
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