Results 71 to 80 of about 101,792 (303)

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source

Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy

Journal of Nanobiotechnology
Diabetic retinopathy (DR) is the major cause of vision decline in adults worldwide. Photoreceptor loss is considered a main pathogenesis of retinal dysfunction in DR.
Yaoxiang Sun, Shenyuan Chen, Xiaoyuan Qi, Yuntong Sun, Zhengmei Jiang, Jie Chang, Yongjun Ma, Jin Huang, Benshuai You, Fengtian Sun   +9 more
doaj   +1 more source

Elementary and macroscopic light-induced currents and their Ca2+-dependence in the photoreceptors of Periplaneta americana

Frontiers in Physiology, 2014
In a microvillar photoreceptor, absorption of an incident photon initiates a phototransduction reaction that generates a depolarizing light-induced current in the microvillus.
Esa-Ville eImmonen, Stephan eKrause, Yani eKrause, Roman eFrolov, Mikko T Vähäsöyrinki, Matti eWeckstrom   +5 more
doaj   +1 more source

Co-Injection of Sulfotyrosine Facilitates Retinal Uptake of Hyaluronic Acid Nanospheres Following Intravitreal Injection

Pharmaceutics, 2021
Gene and drug delivery to the retina is a critical therapeutic goal. While the majority of inherited forms of retinal degeneration affect the outer retina, specifically the photoreceptors and retinal pigment epithelium, effective targeted delivery to ...
Aiden Eblimit, Mustafa S. Makia, Daniel Strayve, Ryan Crane, Shannon M. Conley, Tirthankar Sinha, Ghanashyam Acharya, Muayyad R. Al-Ubaidi, Muna I. Naash   +8 more
doaj   +1 more source

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB, Pearson, RA, Hippert, C, Barber, AC, West, EL, Smith, AJ, Ali, RR   +6 more
core  

Bio‐Inspired Object Retrieval via Proximity‐Guided Adaptive Thigmotactic Exploration and Neuromorphic Recognition

Advanced Robotics Research, EarlyView.
Sparse active‐infrared proximity sensing is coupled to an adaptive thigmotactic controller for camera‐inaccessible object retrieval. After grasping, receptor‐informed encoding transforms force, temperature, and wrist force–torque signals into spike trains for spiking neural network recognition.
Fengyi Wang, Nitish Thakor, Gordon Cheng
wiley   +1 more source

Functional analysis of A 5' untranslated variant in rhodopsin : implications for the retinitis pigmentosa phenotype [PDF]

, 2011
Retinitis Pigmentosa (RP) is a group of heterogeneous retinal degenerative diseases that predominantly affect rod photoreceptor cells. Symptoms include night blindness and gradual peripheral vision loss, which progresses to a complete loss of vision ...
Akinyi, Maureen Veronica
core   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Novel Porcine Retina Cultivation Techniques Provide Improved Photoreceptor Preservation

Frontiers in Neuroscience, 2020
Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries among people over 60 years. It has multiple triggers and risk factors, but despite intense research efforts, its pathomechanisms are currently not ...
Natalie Wagner, Sabrina Reinehr, Maurice R. Gammel, Andrea Greulich, José Hurst, H. Burkhard Dick, Sven Schnichels, Stephanie C. Joachim   +7 more
doaj   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source