iScience, 2020 Summary: The transcription factor NRL (neural retina leucine zipper) has been canonized as the master regulator of photoreceptor cell fate in the retina. NRL is necessary and sufficient to specify rod cell fate and to preclude cone cell fate in mice.
A. Phillip Oel +5 more
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Kiss-and-Run Is a Significant Contributor to Synaptic Exocytosis and Endocytosis in Photoreceptors
Frontiers in Cellular Neuroscience, 2017 Accompanying sustained release in darkness, rod and cone photoreceptors exhibit rapid endocytosis of synaptic vesicles. Membrane capacitance measurements indicated that rapid endocytosis retrieves at least 70% of the exocytotic membrane increase.
Xiangyi Wen +4 more
doaj +1 more source
Evolution of the calcium feedback steps of vertebrate phototransduction [PDF]
Open Biology, 2018 We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the ...
Trevor D. Lamb, David M. Hunt
doaj +1 more source
Vision and retina evolution: How to develop a retina
IBRO Neuroscience Reports, 2022 Early in vertebrate evolution, a single homeobox (Hox) cluster in basal chordates was quadrupled to generate the Hox gene clusters present in extant vertebrates.
Bernd Fritzsch, Paul R. Martin
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Retinal cone photoreceptors of the deer mouse Peromyscus maniculatus : development, topography, opsin expression and spectral tuning [PDF]
, 2013 A quantitative analysis of photoreceptor properties was performed in the retina of the nocturnal deer mouse, Peromyscus maniculatus, using pigmented (wildtype) and albino animals.
Glösmann Martin +8 more
core +2 more sources
β-arrestin functionally regulates the non-bleaching pigment parapinopsin in lamprey pineal. [PDF]
PLoS ONE, 2011 The light response of vertebrate visual cells is achieved by light-sensing proteins such as opsin-based pigments as well as signal transduction proteins, including visual arrestin.
Emi Kawano-Yamashita +5 more
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Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]
, 2015 Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB +34 more
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Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina. [PDF]
PLoS ONE, 2011 The vertebrate retina is known to contain three classes of photoreceptor cells: cones and rods responsible for vision, and intrinsically photoresponsive retinal ganglion cells (RGCs) involved in diverse non-visual functions such as photic entrainment of ...
Paula S Nieto +3 more
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cGMP signaling in vertebrate retinal photoreceptor cells
, 2005 The visual transduction pathway in vertebrate photoreceptors transforms a light stimulus entering the photoreceptor outer segments into an electrical response at the synapses of rod and cone photoreceptor cells.
Zhang, Xiujun, Cote, Rick H.
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Novel rodent models for macular research [PDF]
, 2010 BACKGROUND: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Gesine Huber +54 more
core +2 more sources