Results 1 to 10 of about 32,210 (274)
Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria [PDF]
Nature CommunicationsErythropoietic protoporphyria (EPP) is a genetic disease characterized by protoporphyrin IX-mediated painful phototoxicity. Currently, options for the management of EPP-associated phototoxicity are limited and no oral medication is available.
Junjie Zhu +8 more
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Central scotoma following phacoemulsification surgery: A case report on retinal phototoxicity [PDF]
American Journal of Ophthalmology Case ReportsPhacoemulsification cataract surgery is a widely adopted, however despite its routine application and favorable outcomes, it is not devoid of risks. Complications are rare, with an even more infrequent occurrence of retinal phototoxicity.
Tahmina Nazari, Maarten B. Jalink
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Comparison of Phototoxicity Sensitivity by the Neutral Red Uptake Method for BALB/c 3T3, HaCaT, and HDFa Cells In Vitro [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2022 Introduction: Phototoxicity is an acute photoinduced reaction. The 3T3 neutral red uptake (NRU) phototoxicity test has high sensitivity for the determination of phototoxic substances. To further optimize the method, this study mainly focused on comparing
Qiuwen Liang, Feifei Wang, Xiao Ma
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Validation of a Light Source for Phototoxicity in in vitro Conditions [PDF]
International Journal Bioautomation, 2022 Phototoxicity is a chemically induced skin irritation in the presence of sunlight. Phototoxic substances after irradiation with sunlight absorb and convert light energy into chemical energy, leading to the formation of highly reactive oxygen species with
Ivan Iliev +5 more
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Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2022 Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen +3 more
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Exploration of alternative test methods to evaluate phototoxicity of ophthalmic agents by using Statens Seruminstitut Rabbit Cornea cell lines and 3D human reconstituted cornea models. [PDF]
PLoS ONE, 2018 Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity.
Soyoung Kim, Ki Hwan Choi, Jaesuk Yun
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Locally Administered Photodynamic Therapy for Cancer Using Nano-Adhesive Photosensitizer
Pharmaceutics, 2023 Photodynamic therapy (PDT) is a great potential anti-tumor therapy owing to its non-invasiveness and high spatiotemporal selectivity. However, systemically administered photosensitizers diffuse in the skin and the eyes for a long duration, which cause ...
Yoshiki Komatsu +7 more
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Frontiers in Cell and Developmental Biology, 2021 Phototoxicity is a significant constraint for live cell fluorescence microscopy. Excessive excitation light intensities change the homeostasis of the observed cells.
Rana A. Alghamdi +6 more
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Laboratory Animal Research, 2020 Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established.
Nam Hee Youn +7 more
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Nature Communications, 2020 Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with ...
Xusan Yang +13 more
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