Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria [PDF]
Nature CommunicationsErythropoietic protoporphyria (EPP) is a genetic disease characterized by protoporphyrin IX-mediated painful phototoxicity. Currently, options for the management of EPP-associated phototoxicity are limited and no oral medication is available.
Junjie Zhu +8 more
doaj +2 more sources
Phototoxicity of sporidesmin [PDF]
New Zealand Journal of Agricultural Research, 1969 Abstract Sporidesmin inhibited the germination and growth of seedlings of some plant species. Active transport of glycine-U-14C into excised roots of mustard was reduced by the toxin. Irradiation of sporidesmin with ultra-violet light greatly reduced the toxicity to seeds.
D. E. Wright
openalex +3 more sources
Central scotoma following phacoemulsification surgery: A case report on retinal phototoxicity [PDF]
American Journal of Ophthalmology Case ReportsPhacoemulsification cataract surgery is a widely adopted, however despite its routine application and favorable outcomes, it is not devoid of risks. Complications are rare, with an even more infrequent occurrence of retinal phototoxicity.
Tahmina Nazari, Maarten B. Jalink
doaj +2 more sources
The Curse of the Red Pearl: A Fibroblast-Specific Pearl-Necklace Mitochondrial Phenotype Caused by Phototoxicity [PDF]
BiomoleculesThe dynamic nature of mitochondria makes live cell imaging an important tool in mitochondrial research. Although imaging using fluorescent probes is the golden standard in studying mitochondrial morphology, these probes might introduce aspecific features.
Irene M. G. M. Hemel +3 more
doaj +2 more sources
New Temporin A Analogues Modified in Positions 1 and 10—Synthesis and Biological Studies [PDF]
PharmaceuticsBackground/Objectives: With growing antimicrobial resistance, the overuse of antibiotics, and stagnation in the discovery of new antibiotics, a novel alternative is required to overcome hard-to-treat infections.
Dilyana Dimitrova +5 more
doaj +2 more sources
Comparison of Phototoxicity Sensitivity by the Neutral Red Uptake Method for BALB/c 3T3, HaCaT, and HDFa Cells In Vitro [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2022 Introduction: Phototoxicity is an acute photoinduced reaction. The 3T3 neutral red uptake (NRU) phototoxicity test has high sensitivity for the determination of phototoxic substances. To further optimize the method, this study mainly focused on comparing
Qiuwen Liang, Feifei Wang, Xiao Ma
doaj +1 more source
Validation of a Light Source for Phototoxicity in in vitro Conditions [PDF]
International Journal Bioautomation, 2022 Phototoxicity is a chemically induced skin irritation in the presence of sunlight. Phototoxic substances after irradiation with sunlight absorb and convert light energy into chemical energy, leading to the formation of highly reactive oxygen species with
Ivan Iliev +5 more
doaj +1 more source
Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2022 Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen +3 more
doaj +1 more source
Exploration of alternative test methods to evaluate phototoxicity of ophthalmic agents by using Statens Seruminstitut Rabbit Cornea cell lines and 3D human reconstituted cornea models. [PDF]
PLoS ONE, 2018 Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity.
Soyoung Kim, Ki Hwan Choi, Jaesuk Yun
doaj +1 more source
Locally Administered Photodynamic Therapy for Cancer Using Nano-Adhesive Photosensitizer
Pharmaceutics, 2023 Photodynamic therapy (PDT) is a great potential anti-tumor therapy owing to its non-invasiveness and high spatiotemporal selectivity. However, systemically administered photosensitizers diffuse in the skin and the eyes for a long duration, which cause ...
Yoshiki Komatsu +7 more
doaj +1 more source