Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria [PDF]
Nature CommunicationsErythropoietic protoporphyria (EPP) is a genetic disease characterized by protoporphyrin IX-mediated painful phototoxicity. Currently, options for the management of EPP-associated phototoxicity are limited and no oral medication is available.
Junjie Zhu +8 more
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Central scotoma following phacoemulsification surgery: A case report on retinal phototoxicity [PDF]
American Journal of Ophthalmology Case ReportsPhacoemulsification cataract surgery is a widely adopted, however despite its routine application and favorable outcomes, it is not devoid of risks. Complications are rare, with an even more infrequent occurrence of retinal phototoxicity.
Tahmina Nazari, Maarten B. Jalink
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Assessment of the potential genotoxicity and phototoxicity of triazine UV filters
Journal of Dermatologic Science and Cosmetic TechnologyBackground: Ethylhexyl triazone (EHT) and diethylhexyl butamido triazone (HEB) both belong to the recently developed class of triazine ultraviolet filters. However, their toxicity profiles remain unclear. Objective: To assess the genotoxic and phototoxic
Yilian Wei +9 more
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Comparison of Phototoxicity Sensitivity by the Neutral Red Uptake Method for BALB/c 3T3, HaCaT, and HDFa Cells In Vitro [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2022 Introduction: Phototoxicity is an acute photoinduced reaction. The 3T3 neutral red uptake (NRU) phototoxicity test has high sensitivity for the determination of phototoxic substances. To further optimize the method, this study mainly focused on comparing
Qiuwen Liang, Feifei Wang, Xiao Ma
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Live imaging of whole mouse embryos during gastrulation : migration analyses of epiblast and mesodermal cells [PDF]
, 2013 During gastrulation in the mouse embryo, dynamic cell movements including epiblast invagination and mesodermal layer expansion lead to the establishment of the three-layered body plan.
Ichikawa, Takehiko +6 more
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Exploration of alternative test methods to evaluate phototoxicity of ophthalmic agents by using Statens Seruminstitut Rabbit Cornea cell lines and 3D human reconstituted cornea models. [PDF]
PLoS ONE, 2018 Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity.
Soyoung Kim, Ki Hwan Choi, Jaesuk Yun
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Cell death mechanisms in retinal phototoxicity
Journal of Photochemistry and Photobiology, 2023 Retinal phototoxicity is the main mechanism by which light induces damage to the retina, the sensitive part of the eye. The impact of light on the different retinal layers varies depending on several factors including the wavelength of the incident light,
Anaïs Françon, Alicia Torriglia
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Locally Administered Photodynamic Therapy for Cancer Using Nano-Adhesive Photosensitizer
Pharmaceutics, 2023 Photodynamic therapy (PDT) is a great potential anti-tumor therapy owing to its non-invasiveness and high spatiotemporal selectivity. However, systemically administered photosensitizers diffuse in the skin and the eyes for a long duration, which cause ...
Yoshiki Komatsu +7 more
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Frontiers in Cell and Developmental Biology, 2021 Phototoxicity is a significant constraint for live cell fluorescence microscopy. Excessive excitation light intensities change the homeostasis of the observed cells.
Rana A. Alghamdi +6 more
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Estrogen-Functionalized Ru(II) Polypyridyl Complexes Self-Assemble into Aggregates and Exhibit Selective Phototoxicity against Breast Cancer Cells. [PDF]
Inorg ChemTsoni SA, Kench T, Vilar R, Lazarides T.
europepmc +2 more sources