Results 11 to 20 of about 17,235 (261)

Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

Nature Communications, 2020
Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with ...
Xusan Yang, Zhigang Yang, Zhaoyang Wu, Ying He, Chunyan Shan, Peiyuan Chai, Chenshuo Ma, Mi Tian, Junlin Teng, Dayong Jin, Wei Yan, Pintu Das, Junle Qu, Peng Xi   +13 more
doaj   +1 more source

Shallow- and Deep-Water Ophiura Species Produce a Panel of Chlorin Compounds with Potent Photodynamic Anticancer Activities

Antioxidants, 2023
A Pacific brittle star Ophiura sarsii has previously been shown to produce a chlorin (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (ETPA) (1) with potent phototoxic activities, making it applicable to ...
Antonina Klimenko, Robin Huber, Laurence Marcourt, Dmitry Tabakaev, Alexey Koval, Salim Sh. Dautov, Tatyana N. Dautova, Jean-Luc Wolfender, Rob Thew, Yuri Khotimchenko, Emerson Ferreira Queiroz, Vladimir L. Katanaev   +11 more
doaj   +1 more source

Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms

Pharmaceuticals, 2021
Photosensitivity is one of the most common cutaneous adverse drug reactions. There are two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the number of photosensitization cases is constantly increasing due to excessive
Justyna Kowalska, Jakub Rok, Zuzanna Rzepka, Dorota Wrześniok   +3 more
doaj   +1 more source

Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities

Biosensors, 2023
Time-lapse light microscopy combined with in vitro neuronal cultures has provided a significant contribution to the field of Developmental Neuroscience.
Zrinko Baričević, Zahra Ayar, Samuel M. Leitao, Miranda Mladinic, Georg E. Fantner, Jelena Ban   +5 more
doaj   +1 more source

UVA/UVB Irradiation Exerts a Distinct Phototoxic Effect on Human Keratinocytes Compared to Human Malignant Melanoma Cells

Life, 2023
Solar ultraviolet radiation (UVR) is responsible for the development of many skin diseases, including malignant melanoma (MM). This study assessed the phototoxic effects of UVA, and UVB radiations on healthy and pathologic skin cells by evaluating the ...
Otilia Gag, Ștefania Dinu, Horațiu Manea, Iasmina Marcovici, Iulia Pînzaru, Ramona Popovici, Zorin Crăiniceanu, Zsolt Gyori, Gheorghe Iovănescu, Sorin Chiriac   +9 more
doaj   +1 more source

Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]

Advanced Pharmaceutical Bulletin, 2022
Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen, Gabriel Hancu, Edina Kacsó, Lajos-Attila Papp   +3 more
doaj   +1 more source

Phototoxicity of Lumidoxycycline

Journal of Investigative Dermatology, 1993
Doxycycline (DOTC) is a photosensitizing drug whose mechanism of phototoxicity is complicated by the large variety of stable photoproducts formed. To assess the role of a DOTC photoproduct, lumidoxycycline (LuDOTC), in the photosensitization mechanism of DOTC, MGH-U1 human bladder carcinoma cells were treated in vitro with either DOTC or LuDOTC, and ...
Shea, Christopher R, Olack, Gerard A, Morrison, Harry, Chen, Norah, Hasan, Tayyaba   +4 more
openaire   +2 more sources

Sparse and Random Sampling Techniques for High-Resolution, Full-Field, BSS-Based Structural Dynamics Identification from Video

Sensors, 2020
Video-based techniques for identification of structural dynamics have the advantage that they are very inexpensive to deploy compared to conventional accelerometer or strain gauge techniques. When structural dynamics from video is accomplished using full-
Bridget Martinez, Andre Green, Moises Felipe Silva, Yongchao Yang, David Mascareñas   +4 more
doaj   +1 more source

Increased Level of α2,6-Sialylated Glycans on HaCaT Cells Induced by Titanium Dioxide Nanoparticles under UV Radiation

Nanomaterials, 2018
As one of the most widely used nanomaterials, the safety of nano-TiO2 for human beings has raised concern in recent years. Sialylation is an important glycosylation modification that plays a critical role in signal transduction, apoptosis, and tumor ...
Yuanyuan Ren, Xin Liu, Runqing Geng, Qunwei Lu, Rong Rao, Xi Tan, Xiangliang Yang, Wei Liu   +7 more
doaj   +1 more source

Photobleaching and phototoxicity of mitochondria in live cell fluorescent super-resolution microscopy

Mitochondrial Communications
Photobleaching and phototoxicity can induce detrimental effects on cell viability and compromise the integrity of collected data, particularly in studies utilizing super-resolution microscopes.
Chia-Hung Lee, Douglas C. Wallace, Peter J. Burke   +2 more
doaj   +1 more source