Results 21 to 30 of about 6,711 (234)

Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms

Pharmaceuticals, 2021
Photosensitivity is one of the most common cutaneous adverse drug reactions. There are two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the number of photosensitization cases is constantly increasing due to excessive
Justyna Kowalska, Jakub Rok, Zuzanna Rzepka, Dorota Wrześniok   +3 more
doaj   +1 more source

Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities

Biosensors, 2023
Time-lapse light microscopy combined with in vitro neuronal cultures has provided a significant contribution to the field of Developmental Neuroscience.
Zrinko Baričević, Zahra Ayar, Samuel M. Leitao, Miranda Mladinic, Georg E. Fantner, Jelena Ban   +5 more
doaj   +1 more source

UVA/UVB Irradiation Exerts a Distinct Phototoxic Effect on Human Keratinocytes Compared to Human Malignant Melanoma Cells

Life, 2023
Solar ultraviolet radiation (UVR) is responsible for the development of many skin diseases, including malignant melanoma (MM). This study assessed the phototoxic effects of UVA, and UVB radiations on healthy and pathologic skin cells by evaluating the ...
Otilia Gag, Ștefania Dinu, Horațiu Manea, Iasmina Marcovici, Iulia Pînzaru, Ramona Popovici, Zorin Crăiniceanu, Zsolt Gyori, Gheorghe Iovănescu, Sorin Chiriac   +9 more
doaj   +1 more source

Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]

Advanced Pharmaceutical Bulletin, 2022
Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen, Gabriel Hancu, Edina Kacsó, Lajos-Attila Papp   +3 more
doaj   +1 more source

Phototoxicity of Lumidoxycycline

Journal of Investigative Dermatology, 1993
Doxycycline (DOTC) is a photosensitizing drug whose mechanism of phototoxicity is complicated by the large variety of stable photoproducts formed. To assess the role of a DOTC photoproduct, lumidoxycycline (LuDOTC), in the photosensitization mechanism of DOTC, MGH-U1 human bladder carcinoma cells were treated in vitro with either DOTC or LuDOTC, and ...
Shea, Christopher R, Olack, Gerard A, Morrison, Harry, Chen, Norah, Hasan, Tayyaba   +4 more
openaire   +2 more sources

Sparse and Random Sampling Techniques for High-Resolution, Full-Field, BSS-Based Structural Dynamics Identification from Video

Sensors, 2020
Video-based techniques for identification of structural dynamics have the advantage that they are very inexpensive to deploy compared to conventional accelerometer or strain gauge techniques. When structural dynamics from video is accomplished using full-
Bridget Martinez, Andre Green, Moises Felipe Silva, Yongchao Yang, David Mascareñas   +4 more
doaj   +1 more source

Phototoxicity criteria in NRU test.

, 2018
Phototoxicity criteria in NRU test.
Jaesuk Yun (5244215), Soyoung Kim (117362), Ki Hwan Choi (2368621)   +2 more
core   +1 more source

Increased Level of α2,6-Sialylated Glycans on HaCaT Cells Induced by Titanium Dioxide Nanoparticles under UV Radiation

Nanomaterials, 2018
As one of the most widely used nanomaterials, the safety of nano-TiO2 for human beings has raised concern in recent years. Sialylation is an important glycosylation modification that plays a critical role in signal transduction, apoptosis, and tumor ...
Yuanyuan Ren, Xin Liu, Runqing Geng, Qunwei Lu, Rong Rao, Xi Tan, Xiangliang Yang, Wei Liu   +7 more
doaj   +1 more source

Caffeine as a photoprotective agent for diminishing phototoxicity

, 2010
Skin whitening with Chinese herbal medicine has been used in ancient Asia. However, phototoxicity of the active ingredient limits the application. The modified comet assay was used in the current study to detect DNA crosslinking induced by phototoxicity.
Szeto, Yim Tong Savio, Yim Tong Szeto, Tong Szeto, Tong, Henry Hy, Henry HY Tong, null Yim Tong Szeto, Tong, Henry H.Y.   +5 more
core   +1 more source

KoCVAM-led validation of KeraSkin™ Phototoxicity Assay for inclusion in OECD TG 498

ALTEX: Alternatives to Animal Experimentation
Phototoxicity (or photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after exposure of the body to environmental light.
Nam-Hee Kang, Chang-Eon Park, So-Hee Kim, Eunji Gwak, Seongsook Kim, Min-Gyu Go, Joohwan Kim, Sun-Wook Woo   +7 more
doaj   +1 more source