Results 131 to 140 of about 32,454 (332)

New Temporin A Analogues Modified in Positions 1 and 10—Synthesis and Biological Studies

Pharmaceutics
Background/Objectives: With growing antimicrobial resistance, the overuse of antibiotics, and stagnation in the discovery of new antibiotics, a novel alternative is required to overcome hard-to-treat infections.
Dilyana Dimitrova, Veronica Nemska, Ivan Iliev, Stoyko Petrin, Nelly Georgieva, Dancho Danalev   +5 more
doaj   +1 more source

A Smart Ru‐Locked Chemiluminescence Probe via Bioorthogonal Activation for Highly Selective, Real‐Time and Noninvasive In Vivo Imaging of Thiol Dysregulation

Aggregate, EarlyView.
A smart Ru‐catalyzed chemiluminescence probe based on phenoxy‐adamantyl‐1,2‐dioxetane (PAD) scaffolds is developed for highly sensitive, real‐time in vivo imaging. Featuring a Ru‐locked activation mechanism and a chemiluminophore synthesized via an optimized route, this noninvasive probe enables selective, light‐independent detection of H₂S and thiol ...
Dongnan Guo, Dan Xu, Xiaofeng Wei, Chunying Fan, Bobo Wang, Laifu Li, Haixia Song, Wenguang Yang, Yujie Wang, Zhaojia Wang, Xiaofang Hou, Sicen Wang   +11 more
wiley   +1 more source

The blue light hazard and its use on the evaluation of photochemical risk for domestic lighting. An in vivo study

Environment International
Background: Nowadays artificial light highly increases human exposure to light leading to circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures to photons can induce irreversible retinal damage.
Anaïs Françon, Francine Behar-Cohen, Alicia Torriglia   +2 more
doaj  

Preclinical safety studies of medicines in the Eurasian economic union

Фармакокинетика и Фармакодинамика
This article analyzes the regulatory, scientific, and methodological documents of the Eurasian Economic Union (EAEU) and the Russian Federation devoted to conducting preclinical studies on the safety of medicines.
G. N. Engalycheva, R. D. Syubaev, A. D. Durnev   +2 more
doaj   +1 more source

Boosting the Antimicrobial Activity of Quaternary Ammonium Photosensitizers by Janus‐Type AIE Luminogens

Aggregate, EarlyView.
Novel quaternary ammonium AIE luminogens (AIEgens) with symmetric and Janus structures are rationally designed and prepared for bacteria killings. The integration of experimental and theoretical studies discloses that the Janus‐type AIEgen interacts better with bacterial membranes and shows stronger membrane perturbation, demonstrating superior ...
Dongyang Fan, Meng Li, Zipeng Shen, Ying Li, Jingjing Guo, Dong Wang, Ting Han, Ben Zhong Tang   +7 more
wiley   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
wiley   +1 more source

Role of oxygen radicals in the phototoxicity of tetracyclines toward Escherichia coli B [PDF]

, 1987
Joseph P. Martin, Kenneth Colina, Naomi J. Logsdon   +2 more
openalex   +1 more source

Insight into pericytes in glioblastoma angiogenesis: In vivo tracking by two‐photon microscopy and proteomic profiling

Animal Models and Experimental Medicine, EarlyView.
Based on the inducible pericyte ablation model, we discovered that Pdgfrb+ pericytes regulate glioblastoma (GBM) growth. Using the pericyte lineage tracing model, we revealed their dynamic behavior during GBM angiogenesis. Proteomic analysis combined with pericyte RNA analysis based on human single‐cell data demonstrated cross‐species conserved ...
Qinghong Wang, Chengyan Ma, Xinpei Wang, Mengyuan Li, Xingjiu Yang, Ran Gao   +5 more
wiley   +1 more source

Melolabial Advancement Flap for High-Risk BCC Near the Medial Eye Angle: Phototoxicity/ Photocarcinogenicity Triggered by Nitrosamines in the Polymedication as the Main Cause of Keratinocyte Cancer Development and Progression

Acta Medica Bulgarica
The enigma that lies behind the concept of drug-mediated phototoxicity/ – carcinogenicity remains exciting, as well as not fully elucidated. Nitrosamines remain one of the few reasonable, according to a number of authors, even the only currently directly
Tchernev G., Kordeva S., Hristova A.
doaj   +1 more source

Is blue light solely detrimental for human eyes?

Quality in Sport
It has long been assumed that blue light is solely detrimental to the eyes and that it is a serious risk factor for a number of ocular diseases. In order to gain a more nuanced comprehension of the impact of blue light on the eye and to ascertain ...
Emilia Żurowska, Urszula Guderska, Karolina Krawiel, Marek Król, Jacek Kurzeja, Iga Markowska, Hubert Piotrowicz, Katarzyna Piotrowicz   +7 more
doaj   +1 more source