Results 141 to 150 of about 6,711 (234)

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

open access: yesPhytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko   +3 more
wiley   +1 more source

Tumor microenvironment responsive and nanozyme‐catalyzed photodynamic therapy via lysosome‐localized copper‐doped carbon dots

open access: yesResponsive Materials, EarlyView.
The lysosome‐localized copper‐doped carbon dots (Cu‐MLCDs) leverage the high expression of glutathione (GSH)/H2O2 in the tumor microenvironment to achieve fluorescence reactivation enhancement. Through its multi‐nanozyme activities (glutathione peroxidase, peroxidase, and catalase), this nanoplatform relieves hypoxia, depletes GSH, and synergistically ...
Weixia Qin   +8 more
wiley   +1 more source

Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems

open access: yesSmall, EarlyView.
This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li   +3 more
wiley   +1 more source

Laser‐Synthesized Carbon‐Coated Elemental Bismuth Nanoparticles for Sustained Reactive Oxygen Species Generation Under Visible‐Light Irradiation

open access: yesSmall, EarlyView.
Femtosecond laser ablation of bismuth in acetone yields carbon‐coated nanoparticles with a metallic Bi0 core and an amorphous carbon shell. The core‐shell architecture preserves visible‐light‐driven redox activity and enables sustained hydroxyl‐radical generation.
Pavel Bezrukov   +6 more
wiley   +1 more source

Hydroxy‐Functionalized Near‐Infrared Squaraine Dyes for Advanced Organic Conjugates and Hybrid Materials

open access: yesSmall, EarlyView.
The synthesis of hydroxy‐linker functionalized near‐infrared squaraine dyes is detailed and coupling reactions with silica nanoparticles, polymer end groups and an electron acceptor are demonstrated. New avenues of chemically linked near‐infrared organic conjugates and hybrid materials in fluorescence imaging, as photothermal additives or for ...
Élodie Didier   +6 more
wiley   +1 more source

Synthetic Cells With Chemo‐Optical Signaling Enable Targeted Capture and Killing of Bacteria

open access: yesSmall, EarlyView.
The here presented synthetic cells capture bacteria through their internally produced bioluminescence signal and light activated adhesions. Subsequently, they eliminate the captured bacteria in through a locally elevated hydrogen peroxide concentration generated by membrane bound enzyme.
Xiaoran Zheng   +4 more
wiley   +1 more source

A lysosomal escape‐enabled endoplasmic reticulum‐targeting BODIPY photothermal agent for enhanced tumor ablation

open access: yesSmart Molecules, EarlyView.
To advance precision cancer therapy, we engineered ER‐BDP NPs, a self‐assembled nanomedicine designed for selective ER localization. By integrating organelle targeting with localized laser activation, this agent mediates precision‐guided tumor destruction in vitro and in vivo while reducing off‐target effects, effectively balancing therapeutic efficacy
Shaoyang Shi   +8 more
wiley   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

open access: yesSmart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin   +16 more
wiley   +1 more source

Photostabilized halocyanine for near‐infrared excited bimodal photothermal synergism and tumor‐targeted therapy

open access: yesSmart Molecules, EarlyView.
A series of halogenated organic small molecules were prepared by substituting hydrogen atoms in BC7 molecules with halogen atoms. These chemically modified derivatives displayed significantly improved stability, warming efficiency, and reactive oxygen species generation ability. BC7‐Br and BC7‐Cl showed remarkably enhanced therapeutic efficacy relative
Zongjin Qu   +10 more
wiley   +1 more source

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