Results 161 to 170 of about 6,711 (234)
The FEBS Journal, EarlyView.A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List +2 more
wiley +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source
3SD: Rotational symmetry single‐shot denoising in fluorescence microscopy
Journal of Microscopy, EarlyView.Abstract Image noise is a fundamental problem in fluorescence microscopy analysis, especially in live cell imaging applications where the number of detected photons is limited due to low power of excitation lasers to prevent phototoxicity during extended imaging experiments.
Tijmen H. de Wolf +4 more
wiley +1 more source
From observation to understanding: A multi‐agent framework for smart microscopy
Journal of Microscopy, EarlyView.Abstract Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision‐making and real‐time experimental control.
P. S. Kesavan, Pontus Nordenfelt
wiley +1 more source
Hyperspectral tomographic diffractive microscopy: Development and applications
Journal of Microscopy, EarlyView.Abstract Tomographic Diffractive Microscopy (TDM) provides label‐free three‐dimensional imaging of transparent samples with resolution surpassing confocal limits. At IRIMAS, successive instrumental developments since 2009 have enhanced TDM capabilities through transmission, reflection, isotropic, polarisation‐sensitive, and dual‐view configurations ...
Leonardo Pestana Legori +4 more
wiley +1 more source
20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy
Journal of Microscopy, EarlyView.Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford +3 more
wiley +1 more source
Beyond single cells: Ten years of commercial lattice light‐sheet microscopy
Journal of Microscopy, EarlyView.Abstract Lattice light‐sheet microscopy (LLSM) enables gentle, rapid, volumetric fluorescence imaging of living biological systems. The technique employs Bessel beam interference to produce a light‐sheet which retains its thickness over a relatively large field‐of‐view compared to other light‐sheets.
Helena L. E. Coker, David S. Corcoran
wiley +1 more source
napari‐lattice: A user‐friendly image processing tool for lattice light‐sheet microscopy data
Journal of Microscopy, EarlyView.Abstract Lattice light‐sheet microscopy (LLSM) has revolutionised live‐cell imaging with its ability to resolve sub‐cellular detail with high spatiotemporal resolution and minimal phototoxicity. However, LLSM often generates large terabyte‐scale datasets that require complex preprocessing, creating bottlenecks in storage, data handling and analysis ...
Pradeep Rajasekhar +9 more
wiley +1 more source
Artefact‐aware Brillouin microscopy framework for root mechanical phenotyping
Journal of Microscopy, EarlyView.Abstract Plant roots continuously sense and respond to the mechanical signals of their growth environment: root cap function, mucilage secretion, and hormonal regulation jointly adapt root tip mechanics, shaping whether roots penetrate compacted layers or reorient around obstacles. Most current measurements of root mechanical properties require removal
Timm Landes +6 more
wiley +1 more source