Results 11 to 20 of about 34,272 (324)

Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats

open access: yesLaboratory Animal Research, 2020
Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established.
Nam Hee Youn   +7 more
doaj   +1 more source

Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action

open access: yesCells, 2022
Phototoxicity induced by antibiotics is a real problem in health care. The discontinuation of antibiotic therapy due to a phototoxic reaction can lead to the development of resistant strains.
Justyna Kowalska   +5 more
doaj   +1 more source

Challenges in 3D Live Cell Imaging

open access: yesPhotonics, 2021
A short overview on 3D live cell imaging is given. Relevant samples are described and various problems and challenges—including 3D imaging by optical sectioning, light scattering and phototoxicity—are addressed.
Herbert Schneckenburger, Verena Richter
doaj   +1 more source

Practical Implementation of Log-Scale Active Illumination Microscopy [PDF]

open access: yes, 2010
Active illumination microscopy (AIM) is a method of redistributing dynamic range in a scanning microscope using real-time feedback to control illumination power on a sub-pixel time scale.
K. Chu, Kengyeh   +2 more
core   +3 more sources

A mechanistic study on the phototoxicity of atorvastatin: singlet oxygen generation by a phenanthrene-like photoproduct [PDF]

open access: yes, 2009
Atorvastatin calcium (ATV) is one of the most frequently prescribed drugs worldwide. Among the adverse effects observed for this lipid-lowering agent, clinical cases of cutaneous adverse reactions have been reported and associated with photosensitivity ...
IESCE, MARIA ROSARIA   +4 more
core   +1 more source

Fortifying angiogenic efficacy of conditioned media using phototoxic‐free blue light for wound healing

open access: yesBioengineering & Translational Medicine, 2023
We used a blue organic light‐emitting diode (bOLED) to increase the paracrine factors secreted from human adipose‐derived stem cells (hADSCs) for producing conditioned medium (CM).
Sung‐Won Kim   +3 more
doaj   +1 more source

Neuronal imaging with ultrahigh dynamic range multiphoton microscopy [PDF]

open access: yes, 2017
Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength.
Davison, Ian G.   +4 more
core   +1 more source

Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe

open access: yesNature Communications, 2020
Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with ...
Xusan Yang   +13 more
doaj   +1 more source

Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms

open access: yesFrontiers in Allergy, 2022
Drug-induced photosensitivity (DIP) is a common cutaneous adverse drug reaction, resulting from the interaction of ultraviolet radiations, mostly ultraviolet A, with drugs. DIP includes phototoxicity and photoallergy.
Luca Di Bartolomeo   +10 more
doaj   +1 more source

Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles [PDF]

open access: yes, 2015
The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment. Water soluble gold nanoparticles (ca.
Allen   +49 more
core   +1 more source

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