Results 11 to 20 of about 32,162 (236)
Mechanism of Tetracycline Phototoxicity [PDF]
Journal of Investigative Dermatology, 1984 Studies were made to determine factors important in the phototoxicity mechanism of 7 clinically used tetracyclines (TC). The clinical phototoxicity, the rates of photochemical degradation, and the in vitro phototoxicity of the TCs were qualitatively but not quantitatively correlated.
Hasan, Tayyaba +4 more
openaire +5 more sources
An Optically Stabilized Fast-Switching Light Emitting Diode as a Light Source for Functional Neuroimaging [PDF]
, 2012 Neuroscience research increasingly relies on optical methods for evoking neuronal activity as well as for measuring it, making bright and stable light sources critical building blocks of modern experimental setups. This paper presents a method to control
Wagenaar, Daniel A.
core +21 more sources
Frontiers in Cell and Developmental Biology, 2021 Phototoxicity is a significant constraint for live cell fluorescence microscopy. Excessive excitation light intensities change the homeostasis of the observed cells.
Rana A. Alghamdi +6 more
doaj +1 more source
Laboratory Animal Research, 2020 Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established.
Nam Hee Youn +7 more
doaj +1 more source
Phototoxicity of Lumidoxycycline
Journal of Investigative Dermatology, 1993 Doxycycline (DOTC) is a photosensitizing drug whose mechanism of phototoxicity is complicated by the large variety of stable photoproducts formed. To assess the role of a DOTC photoproduct, lumidoxycycline (LuDOTC), in the photosensitization mechanism of DOTC, MGH-U1 human bladder carcinoma cells were treated in vitro with either DOTC or LuDOTC, and ...
Gerard Olack +4 more
openaire +3 more sources
Practical Implementation of Log-Scale Active Illumination Microscopy [PDF]
, 2010 Active illumination microscopy (AIM) is a method of redistributing dynamic range in a scanning microscope using real-time feedback to control illumination power on a sub-pixel time scale.
K. Chu, Kengyeh +2 more
core +3 more sources
Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles [PDF]
, 2015 The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment. Water soluble gold nanoparticles (ca.
Allen +49 more
core +1 more source
Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts [PDF]
, 2013 Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action.
Bancroft +57 more
core +1 more source
Nature Communications, 2020 Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with ...
Xusan Yang +13 more
doaj +1 more source
PET/PDT theranostics: Synthesis and biological evaluation of a peptide-targeted gallium porphyrin [PDF]
, 2015 The development of novel theranostic agents is an important step in the pathway towards personalised medicine, with the combination of diagnostic and therapeutic modalities into a single treatment agent naturally lending itself to the optimisation and ...
Boyle, Ross W. +3 more
core +1 more source