Results 31 to 40 of about 2,055 (188)

Synthesis and characterization of novel thienyl-phthalazine based heterocyclic systems functionalized with (bi)thiophene moieties [PDF]

, 2017
The phthalazine moiety has a highly -deficient aromatic character that makes it a good deficient aromatic character that makes it a good deficient aromatic character that makes it a good deficient aromatic character that makes it a good deficient ...
Fernandes, S. S. M., Raposo, M. Manuela M.   +1 more
core   +1 more source

Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β‐Hematin Formation from Areas of Enrichment

ChemMedChem, Volume 21, Issue 3, 12 February 2026.
An enrichment map, developed using principal components analysis (PCA), shows the relative abundance of inhibitors of synthetic hemozoin (β‐hematin) formation in antiplasmodium chemical space. This 2‐dimensional landscape can be mined to unearth new chemotypes for antimalarial drug development.
Jessica L. Thibaud, Dirkie C. Myburgh, Rebecca D. Sandlin, Kim Y. Fong, Larnelle F. Garnie, Kathryn J. Wicht, David Kuter, David W. Wright, Timothy J. Egan, Katherine A. de Villiers   +9 more
wiley   +1 more source

Development of a bidentate lewis acid catalyzed inverse electron demand diels-alder reaction of 1,2-diazines for the synthesis of substituted arenes [PDF]

, 2012
The efficient use of resources, as well as the minimization of waste and production costs is now more import than ever. Therefore, the development of new catalytic synthetic methods is an integral part of the research in the field of Organic Chemistry ...
Kessler, Simon Niklaus
core   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

ChemistryEurope, Volume 4, Issue 2, February 2026.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña, Zeyu Feng, David Herrero, Martin Simon, Christopher Golz, Manuel Alcarazo   +5 more
wiley   +1 more source

Chitosan as an eco-friendly heterogeneous catalyst for Michael type addition reactions. A simple and efficient route to pyridones and phthalazines [PDF]

, 2010
Depending on their nature, nitrile activated methylene compounds add readily to β-enaminones in presence of chitosan to yield dienamides, pyridones or pyridine thiones.
Al-Matar, Hamad, Elnagdi, Mohamed, Khalil, Khaled   +2 more
core   +1 more source

Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings [PDF]

, 2023
The synthesis and trypanosomatic behavior of a new series of 1,4-bis(alkylamino)benzo[g]phthalazines 1−4 containing the biologically significant imidazole ring are reported.
Boutaleb-Charki, Samira, Campayo, Lucrecia, Campuzano, Jose, Cano, Carmen, Gómez-Contreras, Fernando, Navarro, Pilar, Osuna, Antonio, Pardo, Mercedes, Sanz, A. M., Sánchez-Moreno, Manuel, Yunta, María J. R.   +10 more
core   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Novel green synthesis of polyfunctionally substituted phthalazines promoted by visible light, DFT studies and molecular docking with antimicrobial and antibiofilm potency

Scientific Reports
Visible-Light-Mediated synthesis is a green and efficient technique that has garnered interest from organic chemists. A new series of polyfunctionally substituted phthalazine derivatives 3a–j were synthesized via a metal-free reaction of pyridazines 1a–d
Ramadan A. Mekheimer, Basma A. Khalifa, Zeinab Shawky Hashem, Samar M. R. Allam, Kamal Usef Sadek, Mohamed R. Eletmany   +5 more
doaj   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, Volume 31, Issue 67, December 1, 2025.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for NAT2 Genotype and Hydralazine Therapy

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1430-1436, December 2025.
Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper‐DeHoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A.G. Agúndez   +18 more
wiley   +1 more source