Results 71 to 80 of about 1,477,998 (362)

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Phylogenetic Factor Analysis [PDF]

Systematic Biology, 2017
51 pages (42 main, 9 supplemental), 9 figures (5 main, 4 supplemental), 4 tables (2 main, 2 supplemental), submitted to Systematic ...
Tolkoff, Max R, Alfaro, Michael E, Baele, Guy, Lemey, Philippe, Suchard, Marc A   +4 more
openaire   +6 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Pre-epidemic evolution of the MRSA USA300 clade and a molecular key for classification

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionUSA300 has remained the dominant community and healthcare associated methicillin-resistant Staphylococcus aureus (MRSA) clone in the United States and in northern South America for at least the past 20 years.
Colleen M. Bianco, Ahmed M. Moustafa, Ahmed M. Moustafa, Kelsey O’Brien, Michael A. Martin, Timothy D. Read, Barry N. Kreiswirth, Paul J. Planet, Paul J. Planet, Paul J. Planet   +9 more
doaj   +1 more source

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

Bioinform., 2009
Summary: Multiple sequence alignments are central to many areas of bioinformatics. It has been shown that the removal of poorly aligned regions from an alignment increases the quality of subsequent analyses.
S. Capella-Gutiérrez, José M. Silla-Martínez, T. Gabaldón   +2 more
semanticscholar   +1 more source

Phylogenetics of Allopolyploids [PDF]

Annual Review of Ecology, Evolution, and Systematics, 2017
We give an overview of recently developed methods to reconstruct phylog-enies of taxa that include allopolyploids that have originated in relatively recent times—in other words, taxa for which at least some of the parental lineages of lower ploidy levels are not extinct and for which ploidy information is clearly shown by variation in chromosome counts.
Oxelman, Bengt, Brysting, Anne Krag, Jones, Graham R, Marcussen, Thomas, Oberprieler, Christoph, Pfeil, Bernard E.   +5 more
openaire   +4 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Uprooted Phylogenetic Networks [PDF]

Bulletin of Mathematical Biology, 2017
The need for structures capable of accommodating complex evolutionary signals such as those found in, for example, wheat has fueled research into phylogenetic networks. Such structures generalize the standard model of a phylogenetic tree by also allowing for cycles and have been introduced in rooted and unrooted form.
Gambette, Philippe, Huber, Katharina, Scholz, Guillaume   +2 more
openaire   +6 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source