Results 131 to 140 of about 238,485 (256)

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Functional and Phylogenetic Diversity [PDF]

Journal of Phylogenetics & Evolutionary Biology, 2016
openaire   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Average-Tree Phylogenetic Diversity of Networks.

Phylogenetic diversity is a measure used to quantify the biodiversity of a set of species. Here, we introduce the "average-tree" phylogenetic diversity score in rooted binary phylogenetic networks and consider algorithms for computing and maximizing the score on a given network. Basically, the score is the weighted average of the phylogenetic diversity
van Iersel, Leo, Schestag, Jannik, Jones, Mark, Scornavacca, Celine, Weller, Mathias   +4 more
openaire   +2 more sources

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity

Angewandte Chemie, EarlyView.
A native ene‐reductase, XenA, was repurposed to catalyze the reverse‐enantioselective desaturation of cyclohexanones. The final variant was obtained through extensive protein engineering, combining PROSS‐guided computational design with mutagenesis and screening.
Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu   +4 more
wiley   +2 more sources

Increases in species richness cause decreases in phylogenetic diversity in Mediterranean and Temperate plant assemblages. [PDF]

Ecology
Luzuriaga AL, Madrigal-González J, de la Cruz M, Olano JM, Peralta J, Escudero A.   +5 more
europepmc   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Amidase‐Catalyzed Desorption of CO2 Captured in Aqueous Monoethanolamine (MEA) Solutions

Angewandte Chemie, EarlyView.
CO2 is captured in aqueous monoethanolamine (MEA) sorbents as carbamate and bicarbonate/carbonate. The subsequent desorption for storage or utilization is energy‐intensive, and this is a major impediment to industrial carbon dioxide removal (CDR) processes. The desorption process can be promoted by enzymes that catalyze the dissociation of distinct CO2‐
Yang Yang, Onur Kırtel, Silke Flindt Badino, Lea Helena Strother, Laura Rotilio, Jerik Mathew Valera Lauridsen, Stefanie Neun, Jens Preben Morth, Ji‐Woong Lee, Ditte Hededam Welner, Peter Westh   +10 more
wiley   +2 more sources

Habitat-specific trends in taxonomic, functional, and phylogenetic diversity in European plant communities over a century. [PDF]

Nat Commun
Kambach S, Jandt U, Acosta ATR, Álvarez-Martínez JM, Axmanová I, Bazzichetto M, Bergmeier E, Bernhardt-Römermann M, Biurrun I, Bonari G, Carboni M, Carlucci MB, Carranza ML, Cerabolini BEL, Chiarucci A, Chytrý M, Damasceno G, Dengler J, De Sanctis M, Divíšek J, Dolezal J, Dullinger S, Essl F, Friesová K, Fontana V, Garbolino E, Glaser M, González-Robles A, Güler B, Hähn GJA, Hájek M, Hruska T, Illa E, Jansen F, Jansen S, Jentsch A, Jiménez-Alfaro B, Daniel Kissling W, Knollová I, Losapio G, Liu U, Lenoir J, Lens F, Lenzner B, Perea AJ, Méndez L, Messier J, Mori AS, Napoleone F, Norum R, Novakovskiy A, Onstein R, Pakeman RJ, Peñuelas J, Petřík P, Pielech R, Pinho BX, Poschlod P, Rašomavičius V, Roscher C, Rossi C, Sabatini FM, Sandel B, Costa DS, Schmidt W, Sheremetiev S, Shovon TA, Spasojevic MJ, Swenson NG, Swacha G, Tarifa R, Tichý L, Tomaselli M, Valdés A, Van Meerbeek K, Vandvik V, Vassilev K, Večeřa M, Weiher E, Wohlgemuth T, Bruelheide H.   +80 more
europepmc   +1 more source