Results 51 to 60 of about 149,860 (254)
Visualizing phylogenetic tree landscapes [PDF]
BMC Bioinformatics, 2017 Genomic-scale sequence alignments are increasingly used to infer phylogenies in order to better understand the processes and patterns of evolution. Different partitions within these new alignments (e.g., genes, codon positions, and structural features) often favor hundreds if not thousands of competing phylogenies. Summarizing and comparing phylogenies
James C. Wilgenbusch +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Cherry picking in forests: A new characterization for the unrooted hybrid number of two phylogenetic trees [PDF]
Discrete Mathematics & Theoretical Computer SciencePhylogenetic networks are a special type of graph which generalize phylogenetic trees and that are used to model non-treelike evolutionary processes such as recombination and hybridization. In this paper, we consider {\em unrooted} phylogenetic networks,
Katharina T. Huber +2 more
doaj +1 more source
A strict upper bound for the partition distance and the cluster distance of phylogenetic trees for each fixed pair of topological trees. [PDF]
PLoS ONE, 2018 For each given pair of (rooted or unrooted) topological trees with the same number of leaves a strict upper bound is shown for the tree partition distance (also called symmetric difference metric and Robinson-Foulds distance)-in case of unrooted trees ...
Martin Middendorf, Nicolas Wieseke
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
TreeSwift: A massively scalable Python tree package
SoftwareX, 2020 Phylogenetic trees are essential to evolutionary biology, and numerous methods exist that attempt to extract phylogenetic information applicable to a wide range of disciplines, such as epidemiology and metagenomics.
N. Moshiri
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Climate-Niche Evolution in Leaf-Warblers (Aves: Phylloscopidae): A Matter of Phylogeny
DiversityMacroevolutionary studies which focus on the development of traits in a phylogenetic context are increasingly used to explore the evolutionary mechanisms and processes that have led to the diversity in species we see today. This includes the study of the
Luisa Gräf +3 more
doaj +1 more source