Results 61 to 70 of about 149,599 (256)

Visualizing phylogenetic tree landscapes [PDF]

BMC Bioinformatics, 2017
Genomic-scale sequence alignments are increasingly used to infer phylogenies in order to better understand the processes and patterns of evolution. Different partitions within these new alignments (e.g., genes, codon positions, and structural features) often favor hundreds if not thousands of competing phylogenies. Summarizing and comparing phylogenies
James C. Wilgenbusch, Wen Huang 0001, Kyle A. Gallivan   +2 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Building a Robust, Densely-Sampled Spider Tree of Life for Ecosystem Research

Diversity, 2020
Phylogenetic relatedness is a key diversity measure for the analysis and understanding of how species and communities evolve across time and space.
Nuria Macías-Hernández, Marc Domènech, Pedro Cardoso, Brent C. Emerson, Paulo Alexandre Vieira Borges, Jesús Lozano-Fernandez, Octávio S. Paulo, Ana Vieira, Alba Enguídanos, François Rigal, Isabel R. Amorim, Miquel A. Arnedo   +11 more
doaj   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Adaptation to Leaf Traits of Individual Trees in a Forest Appears Rare in Caterpillars

Ecology and Evolution
High herbivore abundances on trees surrounded by distantly related neighbors (phylogenetic isolation) might in part be due to local adaptation of herbivores to host trees, but this has not been tested.
Freerk Molleman, Anna Sokół‐Łętowska, Soumen Mallick, Andreas Prinzing, Urszula Walczak   +4 more
doaj   +1 more source

Wald Space for Phylogenetic Trees

, 2021
The recently introduced wald space models phylogenetic trees from an evolutionary perspective. We show that it is a stratified space and propose algorithms to compute geodesics. In application we compute a Frechet mean of three trees of different topologies that is fully resolved, unlike in BHV-space. Both, preliminary results on geodesics and on means
Lueg, Jonas, Garba, Maryam K., Nye, Tom M. W., Huckemann, Stephan F., Nielsen, Frank, Barbaresco, Frédéric   +5 more
openaire   +2 more sources

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

PhyloJS: Bridging phylogenetics and web development with a JavaScript utility library

Ecology and Evolution
There is an increasing number of libraries devoted to parsing, manipulating and visualising phylogenetic trees in JavaScript. Many of these libraries bundle tree manipulation with visualisation, but have limited ability to manipulate trees and lack ...
Leo A. Featherstone, Wytamma Wirth
doaj   +1 more source