Results 71 to 80 of about 512,344 (329)

Hippo pathway phylogenetics predicts monoubiquitylation of Salvador and Merlin/Nf2. [PDF]

open access: yesPLoS ONE, 2012
Recently we employed phylogenetics to predict that the cellular interpretation of TGF-β signals is modulated by monoubiquitylation cycles affecting the Smad4 signal transducer/tumor suppressor. This prediction was subsequently validated by experiments in
Robert G Wisotzkey   +2 more
doaj   +1 more source

The Molecular Phylogeny of Land Plants: Progress and Future Prospects

open access: yesDiversity, 2022
Phylogenetics has become a powerful tool in many areas of biology. Land plants are the most important primary producers of terrestrial ecosystems and have colonized various habitats on Earth.
Guo-Qing Liu, Lian Lian, Wei Wang
doaj   +1 more source

Molecular Phylogenetics

open access: yesEncyclopedia of Bioinformatics and Computational Biology, 2019
We report here the discovery of a remarkable new monotypic mygalomorph spider genus, known only from one geographical location along the central coast of California. The single relict species comprising Cryptocteniza kawtak n. gen. n. sp.

semanticscholar   +1 more source

Invertibility of the TKF model of sequence evolution [PDF]

open access: yes, 2006
We consider character sequences evolving on a phylogenetic tree under the TKF91 model. We show that as the sequence lengths tend to infinity the the topology of the phylogenetic tree and the edge lengths are determined by any one of (a) the alignment of ...
Thatte, Bhalchandra D.
core   +1 more source

Phylogenetic Factor Analysis [PDF]

open access: yesSystematic Biology, 2017
51 pages (42 main, 9 supplemental), 9 figures (5 main, 4 supplemental), 4 tables (2 main, 2 supplemental), submitted to Systematic ...
Tolkoff, Max R   +4 more
openaire   +6 more sources

Positive selection and relaxed purifying selection contribute to rapid evolution of sex-biased genes in green seaweed Ulva

open access: yesBMC Ecology and Evolution
Background The evolution of differences in gamete size and number between sexes is a cornerstone of sexual selection theories. The green macroalga Ulva, with incipient anisogamy and parthenogenetic gametes, provides a unique system to investigate ...
Xiaojie Liu   +6 more
doaj   +1 more source

An Annealed Sequential Monte Carlo Method for Bayesian Phylogenetics. [PDF]

open access: yesSystematic Biology, 2018
We describe an "embarrassingly parallel" method for Bayesian phylogenetic inference, annealed Sequential Monte Carlo (SMC), based on recent advances in the SMC literature such as adaptive determination of annealing parameters.
Liangliang Wang   +2 more
semanticscholar   +1 more source

Using Avida to test the effects of natural selection on phylogenetic reconstruction methods [PDF]

open access: yes, 2004
Phylogenetic trees group organisms by their ancestral relationships. There are a number of distinct algorithms used to reconstruct these trees from molecular sequence data, but different methods sometimes give conflicting results.
Hagstrom, George I.   +3 more
core   +1 more source

The Phylogenetic Likelihood Library [PDF]

open access: yesSystematic Biology, 2014
We introduce the Phylogenetic Likelihood Library (PLL), a highly optimized application programming interface for developing likelihood-based phylogenetic inference and postanalysis software. The PLL implements appropriate data structures and functions that allow users to quickly implement common, error-prone, and labor-intensive tasks, such as ...
Flouri, T.   +7 more
openaire   +6 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

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