Results 71 to 80 of about 5,366,888 (247)

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Physical activity and mental well-being [PDF]

open access: yes, 2013
There is increasing research into the relationship between physical activity and mental health. Evidence shows that for adults at least 30 minutes of moderate intensity physical activity on most days of the week can improve mood and decrease ...
Gauci, Charmaine
core  

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

open access: yesFEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji   +3 more
wiley   +1 more source

Physical activity

open access: yes, 2020
This chapter focuses on physical activity for middle years students. The author defines physical activity in terms of the Australian Health and Physical Education (HPE) curriculum and explores the wide-ranging beliefs and practices related to various approaches to HPE (e.g., sports-centric models).
openaire   +2 more sources

Validity of the new lifestyles NL-1000 accelerometer for measuring time spent in moderate-to-vigorous physical activity in school settings [PDF]

open access: yes, 2010
Current interest in promoting physical activity in the school environment necessitates an inexpensive, accurate method of measuring physical activity in such settings.
American College of Sports Medicine   +15 more
core   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

open access: yesFEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Physical activity promotion [PDF]

open access: yesBritish Journal of General Practice, 2010
Davies and Garbutt wrote an important and commendable editorial on exercise prescription;1 however, there are some fundamental issues raised requiring clarification and further consideration. First, when measured objectively, a staggering 95% of the adult population (UK and US) do not meet the minimum recommended levels of physical activity to confer ...
openaire   +3 more sources

Short- and long-term effects of a multi-component physical activity intervention in primary school [PDF]

open access: yes, 2012
There is compelling evidence that physical activity has numerous health benefits during childhood and adolescence. Insufficient levels of physical activity on the other hand can consequently affect cardiovascular and bone health, which may result in ...
Meyer, Ursina
core   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

open access: yesFEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

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