Results 81 to 90 of about 6,017,492 (315)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Can Habitual Exercise Help Reduce Serum Concentrations of Lipophilic Chemical Mixtures? Association between Physical Activity and Persistent Organic Pollutants [PDF]

, 2020
Yu‐Mi Lee, Ji‐Yeon Shin, Se-A Kim, David R. Jacobs, Duk‐Hee Lee   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effectiveness of Intervention Strategies to Increase Adolescents’ Physical Activity and Reduce Sedentary Time in Secondary School Settings, Including Factors Related to Implementation: A Systematic Review and Meta-Analysis

Sports Medicine - Open
Background Globally, just one in five adolescents meet physical activity guidelines and three-quarters of the school day is spent sitting. It is unclear which types of school-based interventions strategies increase physical activity and reduce sedentary ...
Ana María Contardo Ayala, Kate Parker, Emiliano Mazzoli, Natalie Lander, Nicola D. Ridgers, Anna Timperio, David R. Lubans, Gavin Abbott, Harriet Koorts, Jo Salmon   +9 more
doaj   +1 more source

Effects of beetroot juice supplementation on intermittent high-intensity exercise efforts

Journal of the International Society of Sports Nutrition, 2018
Beetroot juice contains high levels of inorganic nitrate (NO3 −) and its intake has proved effective at increasing blood nitric oxide (NO) concentrations.
Raúl Domínguez, José Luis Maté-Muñoz, Eduardo Cuenca, Pablo García-Fernández, Fernando Mata-Ordoñez, María Carmen Lozano-Estevan, Pablo Veiga-Herreros, Sandro Fernandes da Silva, Manuel Vicente Garnacho-Castaño   +8 more
doaj   +1 more source

Goal Content for the practice of physical activity and the impact on subjective well-being in older adults [PDF]

, 2018
The main goal of this study consisted in an analysis of the impact that the goal content that leads to the practice of physical activity in the elderly population can play on the variables that constitute subjective well-being, as well as to analyze the ...
Antunes, Raul, Cid, Luis, Couto, Nuno, Marinho, Daniel, Monteiro, Diogo, Moutão, João   +5 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Physical activity and mental well-being [PDF]

, 2013
There is increasing research into the relationship between physical activity and mental health. Evidence shows that for adults at least 30 minutes of moderate intensity physical activity on most days of the week can improve mood and decrease ...
Gauci, Charmaine
core  

Associations among neighborhood socioeconomic deprivation, physical activity facilities, and physical activity in youth during the transition from childhood to adolescence [PDF]

, 2019
BACKGROUND: This study aims to examine the longitudinal association of neighborhood socioeconomic deprivation (SED) with physical activity in youth during the transition from elementary to middle school, and to determine if access to physical activity ...
Clennin, Morgan N, Colabianchi, Natalie, Dowda, Marsha, Kaczynski, Andrew, Lian, Min, Pate, Russell R   +5 more
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source