Results 61 to 70 of about 2,048,499 (284)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

On the Foundational Assumptions of Modern Physics [PDF]

, 2015
General relativity and the standard model of particle physics remain our most fundamental physical theories enjoying robust experimental confirmation. The foundational assumptions of physics changed rapidly during the early development of these theories, but the subsequent challenges of their refinement and the exploitation of their explanatory power ...
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Equivalence of the Symbol Grounding and Quantum System Identification Problems

Information, 2014
The symbol grounding problem is the problem of specifying a semantics for the representations employed by a physical symbol system in a way that is neither circular nor regressive.
Chris Fields
doaj   +1 more source

Kinetic modelling of start-up runaway electrons in KSTAR and ITER

Nuclear Fusion, 2023
Understanding the formation of start-up runaway electrons (REs) is essential to ensure successful plasma initiation in ITER. The design of ITER start-up scenarios requires not only predictive simulations but also a validation of assumptions.
Y. Lee, P.C. de Vries, P. Aleynikov, J. Lee, Y.-S. Lee, H.-T. Kim, A.B. Mineev, K.-D. Lee, J.-G. Bak, J.-W. Juhn, Y.-S. Na   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Cryptographic Protocols from Physical Assumptions

, 2019
Moderne Kryptographie erlaubt nicht nur, personenbezogene Daten im Internet zu schützen oder sich für bestimmte Dienste zu authentifizieren, sondern ermöglicht auch das Auswerten einer Funktion auf geheimen Eingaben mehrerer Parteien, ohne dass dabei etwas über diese Eingaben gelernt werden kann (mit der Ausnahme von Informationen, die aus der Ausgabe ...
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Influence of body size on swimming performance of carp (Cyprinus carpio) [PDF]

Acta Ichthyologica et Piscatoria, 1991
The influence of body size on fish swimming performance was investigated. There was a positive correlation between body size and swimming speed. On the contrary, the relations between body size and time of fatigue, fish travel, physical effort were ...
M.H. Mourad
doaj   +3 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source