Results 71 to 80 of about 1,360,407 (261)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Model Latihan Sirkuit Training terhadap Peningkatan Kondisi Fisik Pemain Futsal di Club ZFCA Cidahu

Jurnal Educatio FKIP UNMA
This study aims to analyze the impact of the circuit training model on improving the physical condition of futsal players at ZFCA Cidahu. The research method used a quasi-experimental quantitative approach with a One-Group Pretest-Posttest design.
Cahya Lukmana, Muhammad Saleh, Ahmad Alwi Nurudin   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Components of 24-hour movement behavior and self-reported physical fitness in Ibero-American preschoolers, children, and adolescents during the COVID-19 pandemic

Frontiers in Public Health
ObjectiveTo evaluate the association between the component of 24-h movement behaviors (24HMB) (physical activity—PA; screen time—ST; sleep) and self-reported physical fitness in Ibero-American preschoolers, children, and adolescents during the ...
Letícia de Borba Schneiders, Letícia de Borba Schneiders, José Francisco López-Gil, José Francisco López-Gil, Sofia Fernandez-Gimenez, Sofia Fernandez-Gimenez, Enrique Pintos-Toledo, Enrique Pintos-Toledo, Anelise Reis Gaya, Anelise Reis Gaya, Javier Brazo-Sayavera   +10 more
doaj   +1 more source

Objective criteria for determination of functional-reserve potentials of secondary school age pupils

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2015
Purpose: to substantiate criteria for determination of functional-reserve potentials of secondary school age pupils. Material: 1017 pupils of 5-9 forms from 16 schools were questioned.
I.R. Bodnar, O.V. Rymar, A.V. Solovei, G.G. Malanchuk, P.P. Datskiv   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Impact of Sport Dance on Physical Fitness and Condition in the Opinion of Dancers from [N] Club in [City]

Journal of Education, Health and Sport
Background: Sport dance is a discipline that merges artistic expression with intense physical activity. It engages various motor abilities and may significantly influence physical fitness and conditioning.
Julia Warot, Walery Zukow
doaj   +1 more source

Substantiation and working out of recreation health related technology on the basis of health related hiking and orienteering for junior school age children

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2015
Purpose: to study role of health related hiking and orienteering in improvement of children’s physical conditions. Material: 163 children of 7 - 10 years old age participated in the research (82 boys and 81 girls).
N.N. Goncharova, H.A. Butenko
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source