Results 81 to 90 of about 5,050,783 (290)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Profile of the physical condition of female adolescent volleyball athletes

Sriwijaya Journal of Sport
The purpose of this study was to determine the level of physical condition of adolescent volleyball players in SMP Negeri 01 Kisam Tinggi. This type of research is a qualitative descriptive study with a research sample of 12 teenage female volleyball ...
Titi Harianti, Sukardi Sukardi, Farizal Imansyah   +2 more
doaj   +1 more source

Graded Majorana spinors

, 2006
In many mathematical and physical contexts spinors are treated as Grassmann odd valued fields. We show that it is possible to extend the classification of reality conditions on such spinors by a new type of Majorana condition.
A F Kleppe, Buchbinder I L, Chris Wainwright, DeWitt B, Hawking S W, Ivanov E, Manin Y I, Schunck A F, van Nieuwenhuizen P DeWitt B S Stora R, West P   +9 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An After-School, high-intensity, interval physical activity programme improves health-related fitness in children

Motriz: Revista de Educacao Fisica
Health problems related to a low level of physical activity (PA) in children and adolescents have prompted research into extracurricular PA programs. This study was designed to determine the effects of two different levels of PA on the health-related ...
Sergio Reloba Martínez, Luis Javier Chirosa Ríos, Ignacio Martín Tamayo, Laura Guerrero Almeida, Miguel Angel López-Gomez, Christian Campos Jara   +5 more
doaj   +1 more source

Peculiar features of men physical condition in planning highly intensive physical loads in winter period

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2016
Physical functioning of average and high intensity is an important component of mature men’s health and longevity. For highly intensive physical functioning organism’s physical fitness is required.
O.B. Pryshva
doaj   +1 more source

Canonical versus noncanonical equilibration dynamics of open quantum systems

, 2014
In statistical mechanics, any quantum system in equilibrium with its weakly coupled reservoir is described by a canonical state at the same temperature as the reservoir.
An, Jun-Hong, Li, Yading, Luo, Hong-Gang, Oh, C. H., Yang, Chun-Jie   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Proof that the Hydrogen-antihydrogen Molecule is Unstable

, 2005
In the framework of nonrelativistic quantum mechanics we derive a necessary condition for four Coulomb charges $(m_{1}^+, m_{2}^-, m_{3}^+, m_{4}^-)$, where all masses are assumed finite, to form the stable system.
Carsten Greiner, D. K. Gridnev, E. A. G. Armour, L. D. Landau, M. Reed, R. Courant, W. Thirring   +6 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source