Results 51 to 60 of about 3,304,607 (340)

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Evolving multimorbidity patterns among ageing adults with cardiovascular disease continuum in Southwest China: A longitudinal cohort study

International Journal of Cardiology. Cardiovascular Risk and Prevention
Background: The progression of multimorbidity in Chinese ageing adults with cardiovascular diseases remains inadequately understood. This study investigates the longitudinal evolution of cardiovascular disease continuum (CVDC)-related multimorbidity ...
Xiaoya Qi, Ziyue Zhang, Meng Jia, Yangping Zhang, Shuang Feng, Ruixue Bai, Siyao Wang, Jinning Mao, Shu Su   +8 more
doaj   +1 more source

Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis

Cancer Cell International, 2020
Background Currently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of gastric cancer (GC). We aimed to investigate the role of circ_0008035 in GC progression.
Chang Li, Yuan Tian, Yun Liang, Qingchun Li   +3 more
doaj   +1 more source

Combined atypical primary hypoadrenocorticism and primary hypothyroidism in a dog [PDF]

, 2016
A dog with combined atypical primary hypoadrenocorticism and primary hypothyroidism is described. The dog presented with waxing and waning, vague complaints since more than a year and had been treated with several drugs without complete resolution of ...
Binst, Dominique, Daminet, Sylvie, Martlé, Valentine, Paepe, Dominique, Smets, Pascale, Vanmal, Britt   +5 more
core  

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Nonlinear relationship with saturation effect observed between neutrophil to high-density lipoprotein cholesterol ratio and atherosclerosis in a health examination population: a cross‐sectional study

BMC Cardiovascular Disorders, 2022
Background The relationships between inflammatory indexes and atherosclerosis as well as those between blood lipid indexes and atherosclerosis have been widely studied, but the relationship between the neutrophil to high-density lipoprotein cholesterol ...
Yaqing Zhou, Haijun Dan, Long Bai, Limei Jia, Baojin Lu, Wei Cui   +5 more
doaj   +1 more source

Transcending Big Bang in Loop Quantum Cosmology: Recent Advances [PDF]

, 2008
We discuss the way non-perturbative quantization of cosmological spacetimes in loop quantum cosmology provides insights on the physics of Planck scale and the resolution of big bang singularity.
Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Banerjee K, Bianchi E, Bojowald M, Bojowald M, Corichi A, Corichi A, Corichi A, Dadhich N, Date G, Freidel L, Mielczarek J, Parampreet Singh, Szulc L, Thiemann T, Zhang X   +20 more
core   +3 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Cortisol Secreting Adrenal Adenoma in a 5 Year Old Child [PDF]

, 2011
Adrenal adenoma is a rare endocrinal tumor in children. It can present with features of Cushing's syndrome. We present a case report of five years old female child who came with morbid obesity and hypertension.
Narang, Gursharan Singh, Pahwa, Jivtesh Singh   +1 more
core  

Dynamics of Interacting Scalar Fields in Expanding Space-Time

, 2004
The effective equation of motion is derived for a scalar field interacting with other fields in a Friedman-Robertson-Walker background space-time. The dissipative behavior reflected in this effective evolution equation is studied both in simplified ...
A. Ringwald, A. L. Fetter, Arjun Berera, N. D. Birrel, Rudnei O. Ramos, S. A. Fulling, T. Koide, U. Weiss   +7 more
core   +1 more source