Results 71 to 80 of about 1,150,022 (269)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Sarcopenic obesity definitions and their association with cardiovascular disease and mortality

BMC Geriatrics
Background Sarcopenic obesity (SO) is a prevalent geriatric syndrome with significant implications for cardiovascular health and survival. However, the absence of a standardised diagnostic consensus hinders risk stratification and targeted management in ...
Qian Xu, Rong-Fang Shi, Xiu-Juan Yu, Fan Bu, Kuan Li, Zi-Tong Song, Chen Fang, Hui Li, Yu-Fang Pei   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Computed tomography radiomics of intratumoral and peritumoral microenvironments for identifying the invasiveness of subcentimeter lung adenocarcinomas

BMC Medical Imaging
Background The invasiveness of nodules plays a crucial role in the management and surgical methods selection of lung adenocarcinoma (LAC); however, the ability of traditional chest computed tomography (CT) imaging to detect the invasiveness of ...
Yu-Qiang Zuo, Qing Liu, Tie-Zhi Li, Zhi-Hong Gao, Xu Yang, Yu-Ling Yin, Ping-Yong Feng, Zuo-Jun Geng   +7 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Radiomics-machine learning model for predicting invasiveness of subcentimeter subsolid lung adenocarcinoma: a validation study with external cohort and SHAP interpretability

Frontiers in Oncology
BackgroundPreoperative discrimination of invasive adenocarcinoma (IAC) from pre-invasive lesions in subcentimeter subsolid nodules (SSNs) remains challenging using conventional computed tomography (CT).
Wenfeng Feng, Ruiting Chang, Tiezhi Li, Xiaolong Wang, Zhihong Gao, Xu Yang, Yuling Yin, Yuqiang Zuo   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The Association Between Serum Pentraxin-3 Level at Admission and the Functional Outcome of Patients After Acute Ischemic Stroke: A Meta-Analysis

Balkan Medical Journal
Background: Acute ischemic stroke (AIS) remains a leading cause of disability worldwide, placing a significant burden on patients’ quality of life and healthcare systems.
Yanrong Zhu, Kui Fan, Xujuan Zhao, Kaiwen Hou   +3 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source