Results 31 to 40 of about 200,268 (247)

Origin of life: β‐sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks

FEBS Letters, EarlyView.
The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Physical fitness training for stroke patients [PDF]

Stroke, 2001
Physical fitness is low after stroke. It is unknown whether improving physical fitness after stroke reduces disability.To determine whether fitness training (cardiorespiratory or strength, or both) after stroke reduces death, dependence and disability.
Brazzelli, Miriam, Saunders, David H, Greig, Carolyn A, Mead, Gillian E   +3 more
openaire   +10 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Perfectionism and objective physical health in older adults: a mediational analysis of psychological distress

Health Psychology Report
Background Research has suggested that the relationship between perfectionism and perceived health may be mediated by psychological distress. However, there is a lack of studies that demonstrate this relationship in older adults and that also use ...
Pablo Monteagudo, Alessandra De Maria, Ainoa Roldan, Ana Cordellat-Marzal, Sacramento Pinazo-Hernandis, Cristina Blasco-Lafarga   +5 more
doaj   +1 more source

PHYSICAL FITNESS AND INCIDENT HYPERTENSION: THE FIT PROJECT

Journal of the American College of Cardiology, 2014
Increased physical fitness plays a role in cardiovascular disease prevention. We hypothesized that increased fitness would be inversely associated with incident hypertension (HTN). We examined the association of fitness with incident HTN in 22,109 participants from The FIT (Henry Ford ...
John Schairer, Steven K Keteyian, Michael J. Blaha, Seamus P. Whelton, Steven P. Jones, Roger S. Blumenthal, Stephen P. Juraschek, Mouaz Al-Mallah   +7 more
openaire   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

Journal of Cachexia, Sarcopenia and Muscle
Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26.
Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang   +7 more
doaj   +1 more source

Descriptive Parameters and Its Hysteresis of the Group Separation and Recombination in Bicycle Points Races: Leader’s Velocity and Speed Difference between Leader and Main Group

Applied Sciences, 2023
This study examined the descriptive parameters for separation and recombination processes in a cycling points race. The candidate descriptive parameters were the speed of the leading cyclist and the main group and the difference between their time and ...
Fumihiro Okumura, Keiko Yokoyama, Yuji Yamamoto   +2 more
doaj   +1 more source