Results 41 to 50 of about 868,569 (305)
Comparing Levels of Fitness of Police Officers between Two United States Law Enforcement Agencies Journal of Sports Medicine and Physical [PDF]
, 2018 BACKGROUND: The general physical task demands of law enforcement may suggest that police Officers are of similar fitness levels across cities, states and countries.OBJECTIVE: To investigate whether fitness levels of police Officers from two different ...
Dawes, James +7 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Aerobic fitness impacts sympathoadrenal axis responses to concurrent challenges [PDF]
, 2017 The combination of mental and physical challenges can elicit exacerbated cardiorespiratory (CR) and catecholamine responses above that of a single challenge alone.
Acevedo, Edmund O. +4 more
core +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Journal of EpidemiologyBackground: The novel coronavirus disease 2019 (COVID-19) pandemic may have reduced opportunities for engaging in physical activity (PA) and increased sedentary behavior (SB) among workers.
Yuya Fujii +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Effects of priming exercise on oxygen uptake kinetics, muscle oxygenation, and metabolic load in trained anaerobic athletes: a randomized crossover trial [PDF]
PeerJBackground This study aimed to compare the acute and residual physiological responses elicited by three different priming exercise strategies, including high-intensity priming exercise (HIPE), low-intensity priming exercise (LIPE), and low-intensity ...
Jing Qing +5 more
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2020 Purpose: The aim of this study was to evaluate the potential neurotrophic factors and expression of neurotrophin receptors in peripheral blood mononuclear cells linked with the antidepressant action of exercise intervention during protracted ...
Jue Yang +11 more
doaj +1 more source
Sex-Mediated Differences Among University Students Performing Extreme Physical Activity During The 3-Minute Burpee Test [PDF]
, 2019 Introduction. The aim of this study was to evaluate sex differences in anthropometric indicators, body composition, physical fitness, and physiological parameters in young women and men performing extremely strenuous exercise during the 3-Minute Burpee ...
Clark, Cain +5 more
core +1 more source