Results 31 to 40 of about 295,009 (312)

Frailty in Chinese older adults: the roles of sedentary behavior, relative sit-to-stand power, and their additive interaction

BMC Geriatrics
Background Frailty is a critical geriatric syndrome. While sedentary behavior (SB) and low lower-limb muscle power, which can be efficiently assessed by the 30-second sit-to-stand (STS) test, are independent associated factors for frailty, their additive
Zhu Jiarong, Zhang Xu, Meng Qi, Wang Jingjing, Fan Chaoqun, Wu Yini, Wang Mengdie, Yang Yuting, Feng Qiang   +8 more
doaj   +1 more source

Relationship between behavioral-related variables and dental caries prevalence among university students: a cross-sectional study

Frontiers in Public Health
ObjectivesTo examine the association between behavioral-related variables (physical activity, BMI, dental check-ups) and dental caries prevalence among university students.MethodsA cross-sectional study was conducted among 2,322 university students using
Jiaxin Chen, Xiaoxiao Chen, Chunmiao Wang, Deqiang Zhao, Yanfeng Zhang   +4 more
doaj   +1 more source

A systematic review and meta-analysis on effects of aerobic exercise in people with Parkinson’s disease

npj Parkinson's Disease, 2022
Previous studies have shown that aerobic exercise is an effective way to improve symptoms of Parkinson’s disease (PD). The aim of this study [PROSPERO CRD42022340730] was to explore the effects of aerobic exercises on balance, gait, motor function, and ...
Kai Zhen, Shiyan Zhang, Xifeng Tao, Gen Li, Yuanyuan Lv, Laikang Yu   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects of frequent, short-duration web-based light-intensity aerobic dance exercise on body composition, physical function, and physical activity in older adults: a randomized controlled trial

BMC Geriatrics
Background Physical inactivity remains a critical issue among older adults worldwide, contributing to functional decline and increased health risks. Traditional exercise programs face barriers such as accessibility and motivation. Web-based home exercise
Yuya Watanabe, Kazuki Hyodo, Daisuke Yamaguchi, Takayuki Noda, Sumiyo Nishida, Aiko Ueno, Yuko Kai, Takashi Arao   +7 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Measuring fitness of Kenyan children with polyparasitic infections using the 20-meter shuttle run test as a morbidity metric. [PDF]

, 2011
BACKGROUND: To date, there has been no standardized approach to the assessment of aerobic fitness among children who harbor parasites. In quantifying the disability associated with individual or multiple chronic infections, accurate measures of physical ...
Isabel M. Parraga, Bustinduy, Amaya L, Kitron Uriel, King, CH, Eric M. Muchiri, King, Charles H, Mungai Peter L., Fiutem, JJ, Justin J. Fiutem, Mutuku, Francis, Charles H King, Amaya L Bustinduy, Justin J Fiutem, Parraga Isabel M., Parraga, IM, Kitron, Uriel, Peter L Mungai, Peter L. Mungai, Uriel Kitron, Fiutem, Justin J, Thomas Charles L., Charles L. Thomas, King Charles H., Bustinduy Amaya L., Isabel M Parraga, Eric M Muchiri, Mutuku Francis, Mungai, Peter L, Bustinduy, AL, Muchiri, Eric M, Mutuku, F, Muchiri, EM, Fiutem Justin J., Thomas, Charles L, Charles H. King, Kitron, U, Parraga, Isabel M, Amaya L. Bustinduy, Mungai, PL, Francis Mutuku, Muchiri Eric M., Charles L Thomas, Thomas, CL   +42 more
core   +1 more source

Changes in Accelerometer-measured Physical Activity and Sedentary Behavior From Before to After COVID-19 Outbreak in Workers

Journal of Epidemiology
Background: The novel coronavirus disease 2019 (COVID-19) pandemic may have reduced opportunities for engaging in physical activity (PA) and increased sedentary behavior (SB) among workers.
Yuya Fujii, Naruki Kitano, Yuko Kai, Takashi Jindo, Takashi Arao   +4 more
doaj   +1 more source