Results 51 to 60 of about 295,009 (312)

Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3×Tg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex

Cells, 2022
Alzheimer’s disease (AD) is characterized by deficits in learning and memory. A pathological feature of AD is the alterations in the number and size of synapses, axon length, dendritic complexity, and dendritic spine numbers in the hippocampus and ...
Lianwei Mu, Jiajia Cai, Boya Gu, Laikang Yu, Cui Li, Qing-Song Liu, Li Zhao   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Learn 2 Move 16-24: effectiveness of an intervention to stimulate physical activity and improve physical fitness of adolescents and young adults with spastic cerebral palsy; a randomized controlled trial [PDF]

, 2010
Background: Persons with cerebral palsy (CP) are at risk for developing an inactive lifestyle and often have poor fitness levels, which may lead to secondary health complications and diminished participation and quality of life.
Lindeman, E. (Eline), Reinders-Messelink, Heleen A., Henk J Stam, Stam, Henk J., Wilma M van der Slot, Roebroeck Marij E, van den Berg-Emons, Rita J., Berg-Emons, R.J., Eline Lindeman, Slaman, J. (Jorrit), Stam, H.J., Roebroeck, Marij E.; id_orcid, Slot, W.M.A. (Wilma) van der, van Meeteren Jetty, Meeteren, J. (Jetty) van, Heleen A Reinders- Messelink, Stam, H.J. (Henk), Slaman, J., van den Berg-Emons, Rita J.; id_orcid, van der Slot Wilma M, van Meeteren, Jetty, Roebroeck, M.E., Berg-Emons, H.J.G. (Rita) van den, Marij E Roebroeck, van der Slot, Wilma M., Rita J van den Berg-Emons, Stam Henk J, van der Slot, W.M., Slaman Jorrit, Lindeman Eline, Jorrit Slaman, Jetty van Meeteren, van Meeteren, J., Reinders-Messelink, H.A. (Heleen), Lindeman, Eline, Roebroeck, M.E. (Marij), Reinders- Messelink Heleen A, Slaman, Jorrit, Roebroeck, Marij E., van den Berg-Emons Rita J, Lindeman, E., Reinders-Messelink, H.A.   +41 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Comparison of Children’s Fitness in the Northwest and Southwest of England

, 2014
The data from this paper was gathered from a larger cross-sectional study examining children’s physical activity participation in the Northwest and the Southwest of England. The purpose of this study was to carry out a battery of health and fitness tests
Boyle, Spencer
core   +1 more source

CHARACTERISTICS OF BODY POSTURE IN THE SAGITTAL PLANE AND FITNESS OF FIRST-FORM PUPILS FROM RURAL AREAS [PDF]

, 2014
Purpose: to find correlations between characteristics of body posture in the sagittal plane and fitness and endurance of first-form children from rural areas. Material: an analysis of more than 30 sources of scientific and educational literature. Results:
Muszkieta Radosław, Iermakova Tetiana, Żukowska Hanna, Szark-Eckardt Mirosława   +3 more
core   +1 more source

A combined training program's effect on anthropometry, body composition, physical fitness and blood pressure in elite police

, 2022
Copyright © 2021 EDIZIONI MINERVA MEDICABackground: Combined training (CT) simultaneously associates aerobic and strength exercises. Worldwide, studies on CT´s on Police officers' physical fitness are scarce.
Sá, Mário, Peralta, Miguel, Henriques-Neto, Duarte, Marques, Adilson, Santos, Teresa, Afonso, José   +5 more
core   +1 more source

Perfectionism and objective physical health in older adults: a mediational analysis of psychological distress

Health Psychology Report
Background Research has suggested that the relationship between perfectionism and perceived health may be mediated by psychological distress. However, there is a lack of studies that demonstrate this relationship in older adults and that also use ...
Pablo Monteagudo, Alessandra De Maria, Ainoa Roldan, Ana Cordellat-Marzal, Sacramento Pinazo-Hernandis, Cristina Blasco-Lafarga   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source