Results 51 to 60 of about 868,569 (305)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Current status and related factors of breakfast skipping among adolescents aged 12–15 years in Shandong Province, China: a cross-sectional study

BMC Public Health
Background Regular breakfast consumption is essential for adolescent health, providing critical nutrients for growth, development, and cognitive performance. However, breakfast skipping remains prevalent among adolescents globally and has been associated
Zhihao Huang, Qing Zhang, Chunyang Li, Hanhui Liu, Kunzong Tian   +4 more
doaj   +1 more source

Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3×Tg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex

Cells, 2022
Alzheimer’s disease (AD) is characterized by deficits in learning and memory. A pathological feature of AD is the alterations in the number and size of synapses, axon length, dendritic complexity, and dendritic spine numbers in the hippocampus and ...
Lianwei Mu, Jiajia Cai, Boya Gu, Laikang Yu, Cui Li, Qing-Song Liu, Li Zhao   +6 more
doaj   +1 more source

Georgia's Youth: Overweight and Under-Active [PDF]

, 2004
A statewide assessment of the physical fitness and physical activity levels of Georgia's 5th and 7th ...

core  

Effects of Equal Volume But Different Plyometric Jump Training Intensities on Components of Physical Fitness in Physically Active Young Males [PDF]

, 2019
An 8-week single-blind randomized controlled trial was conducted to compare the effects of separate programs of equal volume, but different intensity, plyometric jump training (PJT), on physical fitness in healthy adults.
Andrade, Argus, Asadi, Balsalobre-Fernandez, Behm, Brumitt, de Villarreal, Ebben, Ebben, Ebben, Flanagan, Granacher, Hopkins, Hopkins, Lees, Markovic, Peng, Piper, Pueo, Radnor, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Ramirez-Campillo, Randell, Read, Ronnestad, Saez-Saez de Villarreal, Sáez de Villarreal, Taube, Thomas, Trecroci, Van Lieshout, Young   +37 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Retrospective and Comparative Analysis of the Physical Fitness of Custody Assistant Classes Prior to Academy Training [PDF]

, 2018
Background Within a law enforcement agency (LEA), custody assistants (CAs) are responsible for upholding proper safety and security inside correctional facilities.
Dawes, James, Dulla, Joe, Fazilat, Bushra, Lockie, Robert G., Orr, Rob Marc, Pakdamanian, Kamran, Stierli, Michael   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Perfectionism and objective physical health in older adults: a mediational analysis of psychological distress

Health Psychology Report
Background Research has suggested that the relationship between perfectionism and perceived health may be mediated by psychological distress. However, there is a lack of studies that demonstrate this relationship in older adults and that also use ...
Pablo Monteagudo, Alessandra De Maria, Ainoa Roldan, Ana Cordellat-Marzal, Sacramento Pinazo-Hernandis, Cristina Blasco-Lafarga   +5 more
doaj   +1 more source

Validation and adaptation of the Physical Activity Enjoyment Scale (PACES) in fitness group exercisers [PDF]

, 2020
Background: Recently, Mullen et al. (2011) presented an 8-item version of the Physical Activity Enjoyment Scale (PACES) providing a valid instrument for assessing enjoyment in physical activity.
Borrego, C., Calmeiro, Luis, Silva, Carlos, Teques, Pedro   +3 more
core   +2 more sources