Results 71 to 80 of about 868,569 (305)

Endurance exercise upregulates mtp expression in aged Drosophila to ameliorate age‐related diastolic dysfunction and extend lifespan

Physiological Reports
Diastolic dysfunction is a major cardiac dysfunction, and an important predisposing factor is age. Although exercise training is often used for the prevention and treatment of cardiovascular disease nowadays, little is currently known about whether ...
Tianhang Peng, Meng Ding, Hanhui Yan, Ping Zhang, Rui Tian, Yin Guo, Lan Zheng   +6 more
doaj   +1 more source

The Health Related Components of Physical Fitness in People with Visual Impairment: A Systematic Review [PDF]

, 2019
Visual impairment is becoming progressively more common in America’s aging society. Physical inactivity contributes to the development of chronic health conditions.
Bell, Sarah, Peterson, Janet T.
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial [PDF]

, 2019
OBJECTIVE: To determine the safety and efficacy of aerobic exercise on activities of daily living in the subacute phase after stroke. DESIGN: Multicentre, randomised controlled, endpoint blinded trial.
Audebert, Heinrich J., Bläsing, Holger, Ebinger, Martin, Endres, Matthias, Flöel, Agnes, Gorsler, Anna, Grittner, Ulrike, Hesse, Stefan, Klostermann, Fabian, Meisel, Andreas, Müller-Werdan, Ursula, Nabavi, Darius G., Nave, Alexander H., Rackoll, Torsten, Steinhagen-Thiessen, Elisabeth   +14 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Single Question of Parent-Reported Physical Activity Levels Estimates Objectively Measured Physical Fitness and Body Composition in Preschool Children: The PREFIT Project [PDF]

, 2019
Physical inactivity is recognized as a determinant of low physical fitness and body composition in preschool children, which in turn, are important markers of health through the lifespan.
Aadahl, Abarca-Gómez, Artero, Cadenas-Sanchez, Cadenas-Sanchez, Cadenas-Sánchez, Cadenas-Sánchez, Cadenas-Sánchez, Cole, de Onis, Emaus, España-Romero, Fang, Geserick, Ho, Jiménez-Pavón, Jiménez-Pavón, Jones, Labayen, Leblanc, Leppänen, Leppänen, Merino-De Haro, Migueles, Minder, Mora-Gonzalez, Murphy, Oliver, Ortega, Ortega, Ortega, Ortega, Ortega, Pate, Ruiz, Sanchez-Delgado, Smith, Umer   +37 more
core   +7 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exercise modality–dependent non-hypertrophic anabolic adaptations in skeletal muscle of rats with type 2 diabetes

Frontiers in Physiology
BackgroundType 2 diabetes mellitus (T2DM) is frequently accompanied by progressive skeletal muscle loss and dysfunction, commonly referred to as diabetic sarcopenia.
Yi-dan Zhang, Yi-dan Zhang, Yi-dan Zhang, Xiang-xing Zhao, Xiang-xing Zhao, Xiang-xing Zhao, Xia Liu, Xia Liu, Xia Liu   +8 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source