Results 71 to 80 of about 5,969,386 (300)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Measuring fitness of Kenyan children with polyparasitic infections using the 20-meter shuttle run test as a morbidity metric. [PDF]

, 2011
BACKGROUND: To date, there has been no standardized approach to the assessment of aerobic fitness among children who harbor parasites. In quantifying the disability associated with individual or multiple chronic infections, accurate measures of physical ...
Isabel M. Parraga, Bustinduy, Amaya L, Kitron Uriel, King, CH, Eric M. Muchiri, King, Charles H, Mungai Peter L., Fiutem, JJ, Justin J. Fiutem, Mutuku, Francis, Charles H King, Amaya L Bustinduy, Justin J Fiutem, Parraga Isabel M., Parraga, IM, Kitron, Uriel, Peter L Mungai, Peter L. Mungai, Uriel Kitron, Fiutem, Justin J, Thomas Charles L., Charles L. Thomas, King Charles H., Bustinduy Amaya L., Isabel M Parraga, Eric M Muchiri, Mutuku Francis, Mungai, Peter L, Bustinduy, AL, Muchiri, Eric M, Mutuku, F, Muchiri, EM, Fiutem Justin J., Thomas, Charles L, Charles H. King, Kitron, U, Parraga, Isabel M, Amaya L. Bustinduy, Mungai, PL, Francis Mutuku, Muchiri Eric M., Charles L Thomas, Thomas, CL   +42 more
core   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Endurance exercise upregulates mtp expression in aged Drosophila to ameliorate age‐related diastolic dysfunction and extend lifespan

Physiological Reports
Diastolic dysfunction is a major cardiac dysfunction, and an important predisposing factor is age. Although exercise training is often used for the prevention and treatment of cardiovascular disease nowadays, little is currently known about whether ...
Tianhang Peng, Meng Ding, Hanhui Yan, Ping Zhang, Rui Tian, Yin Guo, Lan Zheng   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

COMPONENTS OF PHYSICAL FITNESS DIET AND NUTRITION

, 2021
Absolute power Fitness is an allencompassing wellbeing way to deal with upgrading warrior wellbeing and versatility. Nutritional Fitness is a fundamental segment of complete power Fitness as poor nourishment degrades mission readiness and adds to an ...
COMPONENTS OF PHYSICAL FITNESS DIET AND NUTRITION
core  

The relationship between leisure time physical activity and health-related fitness : a single-blinded study [PDF]

, 2013
Includes abstract.Includes bibliographical references.Mature adults are at risk of an accelerated age-related reduction in physical function. Declines in aerobic power, functional strength, motor abilities, flexibility and health-related quality of life ...
Beutel, Anita
core   +1 more source

Exercise modality–dependent non-hypertrophic anabolic adaptations in skeletal muscle of rats with type 2 diabetes

Frontiers in Physiology
BackgroundType 2 diabetes mellitus (T2DM) is frequently accompanied by progressive skeletal muscle loss and dysfunction, commonly referred to as diabetic sarcopenia.
Yi-dan Zhang, Yi-dan Zhang, Yi-dan Zhang, Xiang-xing Zhao, Xiang-xing Zhao, Xiang-xing Zhao, Xia Liu, Xia Liu, Xia Liu   +8 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source