Results 71 to 80 of about 5,371,306 (383)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Sex-Mediated Differences Among University Students Performing Extreme Physical Activity During The 3-Minute Burpee Test [PDF]

, 2019
Introduction. The aim of this study was to evaluate sex differences in anthropometric indicators, body composition, physical fitness, and physiological parameters in young women and men performing extremely strenuous exercise during the 3-Minute Burpee ...
Clark, Cain, Ihász, Ferenc, Kozina, Zhanneta, OMELAN, Aneta, Podstawski, Robert, ŻUREK, Piotr   +5 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Perfectionism and objective physical health in older adults: a mediational analysis of psychological distress

Health Psychology Report
Background Research has suggested that the relationship between perfectionism and perceived health may be mediated by psychological distress. However, there is a lack of studies that demonstrate this relationship in older adults and that also use ...
Pablo Monteagudo, Alessandra De Maria, Ainoa Roldan, Ana Cordellat-Marzal, Sacramento Pinazo-Hernandis, Cristina Blasco-Lafarga   +5 more
doaj   +1 more source

Subjective sleep quality and association with depression syndrome, chronic diseases and health-related physical fitness in the middle-aged and elderly [PDF]

, 2021
Min-Fang Hsu, Kang-Yun Lee, Tsung-Ching Lin, Wen‐Te Liu, Shu‐Chuan Ho   +4 more
openalex   +1 more source

Georgia's Youth: Overweight and Under-Active [PDF]

, 2004
A statewide assessment of the physical fitness and physical activity levels of Georgia's 5th and 7th ...

core  

Relationships Between Reaction Time, Selective Attention, Physical Activity, and Physical Fitness in Children

Frontiers in Psychology, 2019
The objective of this study was to analyze the relationships between simple and complex reaction times (RTs) with the physical activity performed weekly, the physical fitness and selective attention in children of the third cycle of primary education ...
R. Reigal, Silvia Barrero, I. Martín, V. Morales-Sánchez, Rocío Juárez-Ruiz de Mier, A. Hernández-Mendo   +5 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

Journal of Cachexia, Sarcopenia and Muscle
Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26.
Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang   +7 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source