Results 61 to 70 of about 580,444 (263)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The use of wearable resistance and weighted vest for sprint performance and kinematics: a systematic review and meta-analysis

Scientific Reports
Wearable resistance (WR) and weighted vests (WV) can be used in almost all training conditions to enhance sprint performance; however, positioning and additional mass are different in WV and WR strategies, affecting performance and kinematics differently.
Gabriel Felipe Arantes Bertochi, Márcio Fernando Tasinafo Júnior, Izabela A. Santos, Jeffer Eidi Sasaki, Gustavo R. Mota, Gabriela Gregorutti Jordão, Enrico Fuini Puggina   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Room-temperature stabilizing strongly competing ferrielectric and antiferroelectric phases in PbZrO3 by strain-mediated phase separation

Nature Communications
PbZrO3 has been broadly considered as a prototypical antiferroelectric material for high-power energy storage. A recent theoretical study suggests that the ground state of PbZrO3 is threefold-modulated ferrielectric, which challenges the generally ...
Ziyi Yu, Ningbo Fan, Zhengqian Fu, Biao He, Shiguang Yan, Henghui Cai, Xuefeng Chen, Linlin Zhang, Yuanyuan Zhang, Bin Xu, Genshui Wang, Fangfang Xu   +11 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Analysis of the Acute Cytokine Dynamics Induced in Professional Padel According to the Playing Side of the Court and Sex-Related Differences

Metabolites
Background/Objectives: Moderate-intensity physical exercise induces an anti-inflammatory state that may help prevent or manage various diseases. In contrast, high-intensity exercise is closely associated with systemic inflammation, which can lead to ...
María Pía Cádiz-Gallardo, Francisco Pradas, Pamela Patanè, Alejandro García-Giménez, Miguel Lecina, Luis Carrasco   +5 more
doaj   +1 more source

Functional fitness of older women performing physical activities

Revista Brasileira de Cineantropometria e Desempenho Humano, 2010
O envelhecimento é um processo progressivo e natural e a atividade física vem sendo apontada como uma possibilidade de minimizar o seu impacto e, especialmente, manter a capacidade funcional do idoso por mais tempo. O objetivo do presente estudo foi analisar as modificações do Índice de Aptidão Funcional Geral (IAFG) de idosos participan-tes de um ...
Cipriani, Natália Cristina Santos, Meurer, Simone Teresinha, Benedetti, Tania Rosane Bertoldo, Lopes, Marize Amorim   +3 more
openaire   +4 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Association of respiratory function with physical performance, physical activity, and sedentary behavior in older adults

Journal of Physical Therapy Science, 2020
Kaneko H11International University Health and Welfare, Okawa, JapanBackground: Lung function is an important predictor of cardiovascular, respiratory, and all-cause mortality. Several studies have demonstrated that physical performance, physical activity (PA), and sedentary behavior (SB) are associated with respiratory function in older adults. However,
openaire   +3 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source