Results 81 to 90 of about 580,444 (263)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Functional Age Predicted by Electronic Short Physical Performance Battery Can Detect Frailty Status in Older Adults

Clinical Interventions in Aging, 2020
Hee-Won Jung, 1 Taeyang Jin, 1 Ji Yeon Baek, 1 Seongjun Yoon, 2 Eunjoo Lee, 1 Jack M Guralnik, 3 Il-Young Jang 1 1Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; 2Dyphi Research Institute, Dyphi ...
Jung HW, Jin T, Baek JY, Yoon S, Lee E, Guralnik JM, Jang IY   +6 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

AGE PECULIARITIES OF KNEE FUNCTIONALITY AND PHYSICAL PERFORMANCE IN ELDERLY WOMEN

Human Sport Medicine, 2020
Aim. The aim of this study is to learn the effect of the age on degenerative knee joint disease and physical capability of elderly women. Materials and methods. Three groups of relatively healthy elderly women (G1 – 60–64 years (n = 34), G2 – 65–69 years (n = 31) and G3 – 70–74 years (n = 18)) participated in the study.
openaire   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Editorial: Functioning of individuals with cerebral palsy in the 21st century

Frontiers in Rehabilitation Sciences, 2023
Paula Silva de Carvalho Chagas, Hércules Ribeiro Leite   +1 more
doaj   +1 more source

Reduced physical functional performance before hospitalization predicts life support limitations and mortality in nonsurgical intensive care unit patients. [PDF]

Rev Bras Ter Intensiva, 2022
Silva JCGAD, Giraldi T, Coutinho CMG, Carvalho Filho MA, Fernandes DC, Santos TM.   +5 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Association between dependence on activities of daily living and frailty in older people: a comparative study using the clinical-functional vulnerability index-20 and the frailty phenotype

Archives of Gerontology and Geriatrics Plus
Objective: This study aimed to compare the strength of associations between dependence on basic activities of daily living (BADL) and instrumental activities of daily living (IADL) and frailty, assessed by the Clinical-Functional Vulnerability Index-20 ...
Larissa Franciny Souza, PT, Camila Silva de Melo, PT, Artenizia Criste Lima, RDN, Bruno de Souza Moreira, PT, PhD, Henrique Silveira Costa, PT, PhD, Alessandra de Carvalho Bastone, PT, PhD   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source