Results 81 to 90 of about 3,167,735 (339)

Characterization of physical, functional, and cognitive performance in 15 adults with hypophosphatasia

Bone, 2021
Given the small but growing body of literature related to physical functioning and the scarce data related to fine motor and cognitive functioning in adults with hypophosphatasia (HPP), our objective was to characterize physical, functional, and cognitive performance in adults with HPP.
Christina, Durrough, Juan M, Colazo, Jill, Simmons, Jiun-Ruey, Hu, Margaret, Hudson, Margo, Black, Michael, de Riesthal, Kathryn, Dahir   +7 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Feasibility of the Manual Diaphragm Release Technique in Neurocritical Patients on Mechanical Ventilation: A Pilot Randomized Controlled Trial

Medical Sciences
Introduction: This pilot randomized trial evaluated the feasibility of the Manual Diaphragm Release Technique (MDRT) in neurocritical patients on invasive mechanical ventilation (IMV) and explored its immediate effects on diaphragmatic kinematics to ...
Elis Fernanda Araújo Lima de Oliveira, Helga Cecília Muniz de Souza, Heitor Fernandes Silveira Cavalini, Fabianne Maisa de Novaes Assis Dantas, Victor Ribeiro Neves, Fernando de Aguiar Lemos, Marcelo Gama de Abreu, Paulo André Freire Magalhães   +7 more
doaj   +1 more source

Screened hybrid functional applied to 3d^0-->3d^8 transition-metal perovskites LaMO3 (M=Sc-Cu): influence of the exchange mixing parameter on the structural, electronic and magnetic properties

, 2012
We assess the performance of the Heyd-Scuseria-Ernzerhof (HSE) screened hybrid density functional scheme applied to the perovskite family LaMO3 (M=Sc-Cu) and discuss the role of the mixing parameter alpha (which determines the fraction of exact Hartree ...
Cesare Franchini, Hyo-Shin Ahn, J. B. Goodenough, Jiangang He, N. F. Mott, R. G. Parr, V. G. Zubkov, V. G. Zubkov   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Body composition, IGF1 status, and physical functionality in nonagenarians: implications for osteosarcopenia [PDF]

, 2018
OBJECTIVES: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in ...
Cherry, Ke, Jazwinski, Sm, Kim, S, Myers, L, Poggiogalle, E, Ravussin, E., Su, Lj, Welsh, Da   +7 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The association between physical function and hyperkyphosis in older females: Protocol for a systematic review

International Journal of Preventive Medicine, 2022
Identifying factors that impact physical function in older populations is important for the maintenance of good health with aging. Age-related hyperkyphosis, an excessive curvature in the thoracic spine, affects up to 40% of the older adults and is more ...
Marziyeh Mehrabi, Tayebeh Roghani, Diane D Allen, Zahra S Rezaeian, Wendy B Katzman   +4 more
doaj   +1 more source

Functional Measures Developed for Clinical Populations Identified Impairment Among Active Workers with Upper Extremity Disorders [PDF]

, 2015
PURPOSE: Few studies have explored measures of function across a range of health outcomes in a general working population. Using four upper extremity (UE) case definitions from the scientific literature, we described the performance of functional ...
Buckner-Petty, Skye, Dale, Ann Marie, Evanoff, Bradley, Gardner, Bethany T, Kaskutas, Vicki, Rachford, Robert, Strickland, Jaime   +6 more
core   +2 more sources

Associations of Monitor-Assessed Activity with Performance-Based Physical Function

PLOS ONE, 2016
The purpose of this study was to investigate the cross-sectional associations of monitor- derived measures of sedentary time and physical activity with performance-based physical function in healthy Australian adults. Data from 602 participants (mean age 58.1 ± 10.0 years; 58% female) from the 2011/12 wave of the Australian Diabetes, Obesity and ...
Reid, Natasha, Daly, Robin M., Winkler, Elisabeth A. H., Gardiner, Paul A., Eakin, Elizabeth G., Owen, Neville, Dunstan, David W., Healy, Genevieve N.   +7 more
openaire   +6 more sources