Results 91 to 100 of about 538,774 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Association between frailty and pain in older people at high risk of future hospitalization

Frontiers in Pain Research
BackgroundPrevious studies have demonstrated an independent association between pain and frailty, but knowledge about this association with different pain characteristics is limited.ObjectiveThis study was embedded in a prospective, pragmatic, matched ...
Huan-Ji Dong, Joakim Yang, Maria M. Johansson, Maria M. Johansson, Anneli Peolsson, Anneli Peolsson, Marco Barbero, Magnus Nord, Magnus Nord   +8 more
doaj   +1 more source

Changes in disability, self-rated health, comorbidities and psychological wellbeing in community-dwelling 75–95-year-old cohorts over two decades in Helsinki

Scandinavian Journal of Primary Health Care, 2017
Objective: To explore changes in self-reported disabilities, health, comorbidities and psychological wellbeing (PWB) in aged cohorts over two decades. Design, setting and subjects: Cross-sectional cohort studies with postal surveys were conducted among ...
Helena Karppinen, Kaisu H. Pitkälä, Hannu Kautiainen, Reijo S. Tilvis, Jaakko Valvanne, Käthe Yoder, Timo E. Strandberg   +6 more
doaj   +1 more source

Using change management theory to implement the international classification of functioning, disability and health (ICF) in clinical practice

, 2006
Practice Evaluation The success of the International Classification of Functioning, Disability and Health (ICF) depends on its implementation in practice.
Appleby, H
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

White Book on Physical and Rehabilitation Medicine (PRM) in Europe. Chapter 11. Challenges and perspectives for the future of PRM

, 2018
In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper deals with the future perspectives of PRM in Europe according to the actual vision of the European Bodies.
Ceravolo Maria Gabriella, European Physical and Rehabilitation Medicine Bodies Alliance.   +1 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Physical Activity and Physical Function [PDF]

Obstetrics and Gynecology Clinics of North America, 2018
Sheila A. Dugan, Kelley Pettee Gabriel, Brittney S. Lange-Maia, Carrie Karvonen-Gutierrez   +3 more
openaire   +1 more source

White Book on Physical and Rehabilitation Medicine in Europe. Introductions, Executive Summary, and Methodology [PDF]

, 2018
The White Book (WB) of Physical and Rehabilitation Medicine (PRM) in Europe is produced by the 4 European PRM Bodies (European Academy of Rehabilitation Medicine - EARM, European Society of PRM - ESPRM, European Union of Medical Specialists - PRM Section,
Ceravolo Maria Gabriella, European Physical and Rehabilitation Medicine Bodies Alliance, Vetra, Aivars   +2 more
core   +1 more source

The assessment of physical activity and physical functioning.

, 2023
The assessment of physical activity and physical functioning.
Sari Stenholm (631738), Roosa Lintuaho (14203309), Jussi Vahtera (130274), Mikhail Saltychev (3108027), Jaana Pentti (152542)   +4 more
core   +1 more source