Results 111 to 120 of about 538,774 (311)

Endothelial Function and Physical Exercise

Arquivos Brasileiros de Cardiologia, 2018
O endotelio e considerado um tecido ativo e dinâmico com propriedades importantes como manutencao da circulacao sanguinea, regulacao do tonus vascular, permeabilidade microvascular, sinalizacao e angiogenese vascular e resposta inflamatoria. O endotelio permite a conexao entre componentes da circulacao e sistemas do organismo.
Pagan, Luana Urbano, Gomes, Mariana Janini, Okoshi, Marina Politi   +2 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A physical data model for spatio-temporal objects

, 2019
Modellers simulating the state of the physical and biological environment using agents and fields, face the challenge of storing the state variables, like the distribution of biomass and the location and properties of animals. These variables differ from
Landscape functioning, Geocomputation and Hydrology, de Jong, Kor, Landdegradatie en aardobservatie, Karssenberg, Derek, Bureau FG   +4 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

White Book on Physical and Rehabilitation Medicine in Europe. Chapter 2. Why rehabilitation is needed by individual and society

, 2018
In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper describes the background to the context of PRM services and comprises the following: - Epidemiological Aspects of Functioning and Disability - Ethical ...
Ceravolo Maria Gabriella, European Physical and Rehabilitation Medicine Bodies Alliance   +1 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Physical functioning for prostate health

Canadian Urological Association Journal, 2014
Men who undergo long-term androgen-deprivation therapy (ADT) may experience systemic side effects similar to the classical metabolic syndrome. Exercise is a potential strategy for offsetting the adverse effects of ADT among patients with prostate cancer, resulting in improved muscular resistance and positive outcomes on body size and composition ...
openaire   +3 more sources

Immunological, physical and social functioning in varying cases of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

, 2014
Objectives: The purpose of this study is to determine whether immunological, physical and social functioning varies in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients that meet different diagnostic criteria for the illness, and ...
Staines, Don, Hardcastle, Sharni Lee, Marshall-Gradisnik, Sonya, Johnston, Samantha, Ramos, Sandra Bahia, Brenu, Ekua, Huth, Teilah Kathryn, Fuller, Kirsty   +7 more
core  

Nutritional influences on human neurocognitive functioning

, 2014
The notion that good nutrition is essential for adequate growth and sound physical wellbeing is very well established. Further, in recent years, there has been an overwhelming increase in research dedicated to better understanding how nutritional factors
Scholey, Andrew, Michael A Smith, Andrew B Scholey, Michael A. Smith, Michael Smith, Andrew Scholey, Smith, Michael, Andrew B. Scholey   +7 more
core   +1 more source