Results 101 to 110 of about 538,774 (311)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hearing Loss and Physical Functioning Among Adults with Heart Failure: Data from NHANES [Corrigendum]

Clinical Interventions in Aging, 2020
Cosiano MF, Jannat-Khah D, Lin FR, Goyal P, McKee M, Sterling MR   Page 635, Abstract, Methods, the text “Multiple imputation was used to examine the association” should read “Negative binomial regression was used to examine the ...
Cosiano MF, Jannat-Khah D, Lin FR, Goyal P, McKee M, Sterling MR   +5 more
doaj  

Personal meaning in relation to daily functioning of a patient in physical therapy practice: Narratives of a patient, a family member and physical therapist

, 2017
Purpose: To get insight into personal meaning of a person involved in a physical therapy intervention. Methods: Mrs. A, a 76-year-old woman is referred to a physical therapist (PT) for assessment of functioning and training before total hip arthroplasty (
Willem Marie Speelman (4862443), Oosting, Ellen, Jaap Dronkers, Ellen Oosting (160630), Dronkers, J.J., Hoogeboom, Thomas J., Oosting, E., Ellen Oosting, Speelman, Willem Marie; id_orcid, Nico van Meeteren, Dronkers, Jaap, Willem Marie Speelman, Thomas Hoogeboom, Hoogeboom, Thomas, Hoogeboom, T.J., Nico van Meeteren (499078), Meeteren, N. van, Van Meeteren, Nico, Thomas Hoogeboom (3571883), Speelman, Willem Marie, Jaap Dronkers (3841561), Meeteren,van, Nico L.U.   +21 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Cyber Physical System Technology for the Monitoring of Stomatognathic System Functioning

, 2017
The present research project aims at designing, implementing and validating a cyber physical system (CPS) for the real time monitoring and analysis of diverse static and dynamic aspects during the functioning of the stomatognathic system. The main focus
D'ADDONA, DORIANA MARILENA
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A brief assessment of physical functioning for prostate cancer patients

, 2010
Jin-Shei Lai1, Rita Bode2, Hwee-Lin Wee3, David Eton4, David Cella11Department of Medical Social Sciences, 2Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, IL USA; 3Department of Pharmacy ...
Hwee-Lin Wee, Rita Bode, et al, Jin-Shei Lai   +3 more
core  

White book on physical and rehabilitation medicine (PRM) in Europe. Chapter 7.The clinical field of competence: PRM in practice

, 2018
In the context of the White Book on Physical and Rehabilitation Medicine (PRM) in Europe this paper deals with the scope and competencies of PRM starting from its definition as the "medicine of functioning." PRM uses the rehabilitative health strategy as
Ceravolo Maria Gabriella, European Physical and Rehabilitation Medicine Bodies Alliance   +1 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source