Results 111 to 120 of about 21,138,521 (345)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Events and event records (scoring and penalties) across temporal units in elite judo contests: implications for tactical preparation

Revista de Artes Marciales Asiáticas
Introduction: This study examines the distribution of events and event records (EVRs) in elite judo competitions, encompassing both male and female categories.
Xurxo Dopico-Calvo, Luis Santos, Eduardo Carballeira, Xian Mayo, Bayram Ceylan, Jožef Simenko , Marta Sevilla-Sanchez, Eliseo Iglesias-Soler   +7 more
doaj   +5 more sources

Factorization in the Cloud: Integer Factorization Using F# and Windows Azure [PDF]

, 2011
Implementations are presented of two common algorithms for integer factorization, Pollard’s “p – 1” method and the SQUFOF method. The algorithms are implemented in the F# language, a functional programming language developed by Microsoft and officially ...
Shaffer, Ryan
core   +1 more source

Effect of septoplasty on physical performance

Quality in Sport
The nasal septum is a key component of the nasal structure, affecting proper airflow and providing support for the nasal structures. A deviated septum (DSN) can lead to breathing disorders, impaired nasal patency, recurrent nosebleeds, olfactory disorders and frequent upper respiratory tract infections.
Patryk Śliwiak, Aneta Kondratowicz, Paweł Miłkowski, Marta Głąbień, Daria Aleksandrowicz, Anna Kuśnierz, Zofia Jakubczak, Karolina Kusiak, Olga Wieczorek, Maria Weronika Zimniak   +9 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Performance of Joint Channel and Physical Network Coding Based on Alamouti STBC

, 2013
This work considers the protograph-coded physical network coding (PNC) based on Alamouti space-time block coding (STBC) over Nakagami-fading two-way relay channels, in which both the two sources and relay possess two antennas.
Fang, Yi, Tong, Kin-Fai, Wang, Lin, Wong, Kai-Kit, 王琳   +4 more
core   +1 more source

Age‐dependent changes in physical performance and body composition in community‐dwelling Japanese older adults

Journal of Cachexia, Sarcopenia and Muscle, 2017
The aim of this study was to describe the age‐dependent changes in the parameters of physical performance and body composition in Japanese older adults who are independently dwelling in the community.
H. Makizako, H. Shimada, T. Doi, K. Tsutsumimoto, Sangyoon Lee, Sung Chul Lee, K. Harada, R. Hotta, S. Nakakubo, S. Bae, K. Harada, Daisuke Yoshida, K. Uemura, Yuya Anan, Hyuntae Park, Takao Suzuki   +15 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of Low-Load and Low-Volume Squat Training Combined with Plyometrics During a Full Season on Physical Performance in Young Soccer Players

Sports
The aim of this study was to analyze the effects of a 24-week low-load, low-volume resistance training (RT) program combined with plyometric exercises on the physical performance of U-15 male soccer players.
Felipe Franco-Márquez, Carmen Serrano-Cañadillas, Juan Manuel Yáñez-García, Juan José González-Badillo, David Rodríguez-Rosell   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source