Results 141 to 150 of about 21,138,521 (345)

Facts about Iowa Law Enforcement Physical Standards for Pre-employment Testing, 2011 [PDF]

open access: yes, 2011
The Iowa Law Enforcement Academy Council, in recognizing the importance of physical fitness status for job performance, established this physical test regimen as a employment standard effective February 15, 1993.

core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Performance evaluation capabilities for the design of physical systems [PDF]

open access: yes
The results are presented of a study aimed at developing and formulating a capability for the limiting performance of large steady state systems. The accomplishments reported include: (1) development of a theory of limiting performance of large systems ...
Pilkey, W. D., Wang, B. P.
core   +1 more source

Performance Analysis of PCFICH and PDCCH LTE Control Channels [PDF]

open access: yes, 2014
Control channels play a key role in the evaluation of mobile system performance. The purpose of our paper is to evaluate the performance of the control channels implementation in the Long Term Evolution (LTE) system.
Hanus, S., Milos, J.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Performance optimization of an MHD generator with physical constraints [PDF]

open access: yes
A method to optimize the Faraday MHD generator performance under a prescribed set of electrical and magnet constraints is described. The results of generator performance calculations using this technique are presented for a very large MHD/steam plant ...
Pian, C. C. P.   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Effects of 12 Weeks of Combined Exercise on Heart Rate Variability and Dynamic Pulmonary Function in Obese and Elderly Korean Women

open access: yesIranian Journal of Public Health, 2018
Background: We investigated whether a combination of aerobic and resistance exercise administered over a period of 12 weeks enhanced heart rate variability (HRV) and dynamic pulmonary function (DPF) in obese and elderly Korean women. Methods: The study
Jisu KIM, Hun-Young PARK, Kiwon LIM
doaj  

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