Results 91 to 100 of about 13,668,844 (253)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Physical properties of sediment core SO93-22KL

, 1997
Physical properties of sediment core SO93 ...
Wiedicke-Hombach, Michael, Niessen, Frank, Kuhn, Gerhard, Michael Wiedicke-Hombach (6973556), Weber, Michael E, Michael E Weber (6962675), Frank Niessen (6975911), Gerhard Kuhn (6959462)   +7 more
core   +1 more source

Non-destructive histomorphological identification of Late Pleistocene burned bone fragments using synchrotron radiation X-ray CT at SPring-8

Scientific Reports
Fukui Cave, located in the southwestern Japanese Archipelago, is a cave site containing cultural layers dating from the Late Pleistocene to the early Holocene.
Junmei Sawada, Minoru Yoneda, Kentaro Uesugi, Masato Hoshino, Seiya Watanabe, Naoki Miyamoto, Kazuhiro Uzawa, Takeji Toizumi, Rin Anbo, Fumiko Saeki, Yuzo Yanagita   +10 more
doaj   +1 more source

Grain refining in copper foil induced by ultrasonic field during the electrodeposition process

Ultrasonics Sonochemistry
Electrodeposition is a key technique for fabricating ultra-thin copper foils, where grain refinement plays a critical role in determining their mechanical performance.
Chengwen Wu, Xiaolong Ren, Lin Xie, Wenhua Wu, Zhiwei Liu, Wei Zhai, Jianyuan Wang   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Physical properties of sediment core PS2876-2

, 2006
Physical properties of sediment core PS2880-
Kleiber, Hans Peter, Niessen, Frank, Frank Niessen (6975911), Hans Peter Kleiber (7893533)   +3 more
core   +1 more source

Selected physical properties of liquid biofuels

Research in Agricultural Engineering, 2013
The goal of this study was the determination of basic physical properties such as density, calorific value and rheological properties of liquid biofuels. Biofuels on the base of bioethanol and rapeseed methyl ester were chosen.
P. Trávníček, M. Valach, Z. Hlaváčová, J. Mareček, T. Vítěz, P. Junga   +5 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Physical properties of sediment core SO93-124KL

, 1997
Physical properties of sediment core SO93 ...
Wiedicke-Hombach, Michael, Niessen, Frank, Kuhn, Gerhard, Michael Wiedicke-Hombach (6973556), Weber, Michael E, Michael E Weber (6962675), Frank Niessen (6975911), Gerhard Kuhn (6959462)   +7 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source