Results 91 to 100 of about 4,948,518 (287)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Physical properties of Ce3-xTe4 below room temperature

, 2012
The physical properties of polycrystalline Ce3-xTe4 were investigated by measurements of the thermoelectric properties, Hall coefficient, heat capacity, and magnetization.
Andrew F. May, Brian C. Sales, Claudia Cantoni, G. G. Gadzhiev, Michael A. McGuire, V. I. Fistul, V. P. Zhuze, V. V. Tikhonov   +7 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Production of the Volume Composite Based on Bi2Te3-SiO2 Nanoparticles and its Electroconductivity [PDF]

Журнал нано- та електронної фізики, 2015
The nanoparticles of Bi2Te3-SiO2 were synthesized by microwave solvotermal recovery of oxide precursors of bismuth and tellurium with simultaneous hydrolysis of tetraethylorthosilicate (TEOS).
M.N. Yapryntsev, R.A. Lyubushkin, E.N. Alifanova, O.N. Ivanov, L.V. Malikov   +4 more
doaj  

A pathway towards proper modeling of physical properties

, 2018
Theoretical concepts in condensed matter physics are typically verified and also developed by exploiting computer simulations mostly in simple models. Predictions based on these usually isotropic models are often at odds with measurement results obtained
Grzybowski, A., Koperwas, K., Paluch, M.
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Physical properties underlying observed kinematics of satellite galaxies

, 2013
We study the kinematics of satellites around isolated galaxies selected from the Sloan Digital Sky Survey (SDSS) spectroscopic catalog. Using a model of the phase-space density previously measured for the halos of LCDM dark matter cosmological ...
Abazajian, Amorisco, An, Ascasibar, Bertin, Binney, Biviano, Blanton, Brainerd, Bryan, Cappellari, Chabrier, Chilingarian, Cole, Conroy, Cuesta, Das, de Lorenzi, Dejonghe, Dekel, Dutton, Gary A. Mamon, Gavazzi, Gelman, Gnedin, Grillo, Guo, Hansen, Hansen, Humphrey, Hyde, Hénon, Kauffmann, Kazantzidis, Klypin, Klypin, Komatsu, Koopmans, Koopmans, Leauthaud, Ludlow, Mamon, Mamon, Mamon, Mandelbaum, Mandelbaum, Mandelbaum, McKay, Merrifield, Merritt, More, Napolitano, Navarro, Navarro, Navarro, Prada, Radosław Wojtak, Roche, Rozo, Sales, Salim, Schulz, Sersic, Simard, Sofue, Springel, Springel, Tully, van den Bosch, Wojtak, Wojtak, Wojtak, Wojtak, Wojtak, Yegorova, Zaritsky, Zaritsky, Zhao, Łokas, Łokas, Łokas, Łokas   +81 more
core   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source