Results 41 to 50 of about 428,539 (263)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Severely atrophic human muscle fibers with nuclear misplacement survive many years of permanent denervation

European Journal of Translational Myology, 2016
Likewise in rodents, after complete spinal cord injury (SCI) the lower motor neuron (LMN) denervated human muscle fibers lose completely the myofibrillar apparatus and the coil distribution of myonuclei that are relocated in groups (nuclear clumps) in ...
Ugo Carraro, Helmut Kern
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Biology of muscle atrophy and of its recovery by FES in aging and mobility impairments: roots and by-products

European Journal of Translational Myology, 2015
There is something in our genome that dictates life expectancy and there is nothing that can be done to avoid this; indeed, there is not yet any record of a person who has cheated death.
Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Simone Mosole, Sandra Zampieri, Valerio Gobbo, Barbara Ravara, Francesco Piccione, Andrea Marcante, Alfonc Baba, Sheila Schils, Amber Pond, Francesco Gava   +15 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Tele-rehabilitation using transcranial direct current stimulation combined with exercise in people with spinal cord injury: a randomized controlled trial

Journal of Rehabilitation Medicine
Objective: This study explored the effects of home-based transcranial direct current stimulation combined with exercise on motor and sensory function, spasticity, functional and transfer performance, and quality of life.
Thanwarat Chantanachai, Irin Apiworajirawit, Pipat Klamruen, Benchaporn Aneksan, Paradee Auvichayapat, Alexandra Lackmy-Vallée, Wanalee Klomjai   +6 more
doaj   +1 more source

Physical stimulations and their osteogenesis-inducing mechanisms

International Journal of Bioprinting
Physical stimulations such as magnetic, electric and mechanical stimulation could enhance cell activity and promote bone formation in bone repair process via activating signal pathways, modulating ion channels, regulating bonerelated gene expressions, etc.
Shuai, Cijun, Yang, Wenjing, Peng, Shuping, Gao, Chengde, Guo, Wang, Lai, Yuxiao, Feng, Pei   +6 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Home-based Functional Electrical Stimulation for long-term denervated human muscle: History, basics, results and perspectives of the Vienna Rehabilitation Strategy

European Journal of Translational Myology, 2014
We will here discuss the following points related to Home-based Functional Electrical Stimulation (h-b FES) as treatment for patients with permanently denervated muscles in their legs: 1.
Helmut Kern, Ugo Carraro
doaj   +3 more sources

Use of Surface EMG in Clinical Rehabilitation of Individuals With SCI: Barriers and Future Considerations

Frontiers in Neurology, 2020
Surface electromyography (sEMG) is a widely used technology in rehabilitation research and provides quantifiable information on the myoelectric output of a muscle.
Rakesh Pilkar, Rakesh Pilkar, Kamyar Momeni, Kamyar Momeni, Arvind Ramanujam, Manikandan Ravi, Erica Garbarini, Gail F. Forrest, Gail F. Forrest, Gail F. Forrest   +9 more
doaj   +1 more source