Results 61 to 70 of about 1,165,212 (259)

Calorie restriction regime enhances physical performance of trained athletes

Journal of the International Society of Sports Nutrition, 2018
Background Caloric restriction induces mitochondrial biogenesis and improves physical fitness in rodents. We aimed to provide evidence of how caloric restriction affects the body composition and physical performance of trained athletes and to evaluate ...
Victoria Pons, Joan Riera, Xavier Capó, Miquel Martorell, Antoni Sureda, Josep A. Tur, Franchek Drobnic, Antoni Pons   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Long Limb Bones Asymmetry in the Ancient Population of the Volga-Ural Steppe (Neolithic – Middle Ages)

Нижневолжский археологический вестник
The work is devoted to the study of the phenomenon of directional bilateral asymmetry of long limb bones in the population of the Volga-Ural steppe on the basis of osteometric data from the Neolithic/Eneolithic, Early and Late Bronze, Early Iron Age, and
Artem P. Grigorev
doaj   +1 more source

Effects of Different Types of Exercise Training on the Cortisol Awakening Response in Children

Frontiers in Endocrinology, 2019
Context: Due to great variability of the hypothalamus-pituitary-adrenal (HPA)-axis, research has to produce better-controlled findings to make a more meaningful statement regarding the effect of exercise training (ET) on the cortisol awakening response ...
Mirko Wegner, Flora Koutsandréou, Anett Müller-Alcazar, Franziska Lautenbach, Henning Budde   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Physical training in patients with chronic heart failure

Кардиоваскулярная терапия и профилактика, 2009
Chronic heart failure (CHF) manifests in heart insufficiency and inadequate blood flow in various organs and tissues. One of the most important CHF symptoms is reduced physical stress (PS) tolerability, due to impaired central hemodynamics and various ...
A. V. Snytnikova, D. A. Andreev, A. A. Doletsky, A. V. Svet, A. V. Chaplygin   +4 more
doaj  

Assessment of Fertility in Female Offspring of Stressed Male Rats Treated with Sulpiride

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Chronic stress has detrimental effects on reproductive system. Offspring are likely to be vulnerable to adverse effects from antipsychotic medication and stress transmitted through gonads and gametes.
Shahla Amiri, Farrin Babaei-Balderlou, Gholamreza Najafi   +2 more
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source