Results 71 to 80 of about 9,189,271 (249)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Calorie restriction regime enhances physical performance of trained athletes

open access: yesJournal of the International Society of Sports Nutrition, 2018
Background Caloric restriction induces mitochondrial biogenesis and improves physical fitness in rodents. We aimed to provide evidence of how caloric restriction affects the body composition and physical performance of trained athletes and to evaluate ...
Victoria Pons   +7 more
doaj   +1 more source

White Book on Physical and Rehabilitation Medicine (PRM) in Europe. Chapter 11. Challenges and perspectives for the future of PRM

open access: yes, 2018
In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper deals with the future perspectives of PRM in Europe according to the actual vision of the European Bodies.
Ceravolo Maria Gabriella   +1 more
core   +1 more source

Problems in using a comb sample as a stress-free reference for the determination of welding residual stress by diffraction [PDF]

open access: yes, 2010
Precise measurement of a stress-free reference lattice parameter is vital in the determination of residual stress by diffraction techniques using θ/2θ-based analyses.
Ganguly S   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Physical training in patients with chronic heart failure

open access: yesКардиоваскулярная терапия и профилактика, 2009
Chronic heart failure (CHF) manifests in heart insufficiency and inadequate blood flow in various organs and tissues. One of the most important CHF symptoms is reduced physical stress (PS) tolerability, due to impaired central hemodynamics and various ...
A. V. Snytnikova   +4 more
doaj  

Long Limb Bones Asymmetry in the Ancient Population of the Volga-Ural Steppe (Neolithic – Middle Ages)

open access: yesНижневолжский археологический вестник
The work is devoted to the study of the phenomenon of directional bilateral asymmetry of long limb bones in the population of the Volga-Ural steppe on the basis of osteometric data from the Neolithic/Eneolithic, Early and Late Bronze, Early Iron Age, and
Artem P. Grigorev
doaj   +1 more source

Effects of Different Types of Exercise Training on the Cortisol Awakening Response in Children

open access: yesFrontiers in Endocrinology, 2019
Context: Due to great variability of the hypothalamus-pituitary-adrenal (HPA)-axis, research has to produce better-controlled findings to make a more meaningful statement regarding the effect of exercise training (ET) on the cortisol awakening response ...
Mirko Wegner   +4 more
doaj   +1 more source

Traumatic events and physical health in a New Zealand community sample

open access: yes, 2002
Traumatic event exposure and physical health were examined in a community-residing sample of 1,500 New Zealand adults. Half (51%) reported past traumatic event exposure, 9% reported recent (past 12 months) trauma exposure, and 40% reported no exposure ...
Flett RA   +4 more
core   +1 more source

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