Results 71 to 80 of about 3,747,500 (296)

Prevalence and Predictors of Burnout Among Medical Students in a Private Medical College: A Cross-Sectional Study

open access: yesNational Board of Examinations Journal of Medical Sciences
Background: Medical students are consistently subjected to psychosocial stresses during their training, which can result in burnout, a condition characterised by emotional, mental, and physical weariness due to severe and protracted stress.
Manjunath M E   +2 more
doaj   +1 more source

Gravitational Superenergy Tensor

open access: yes, 1996
We provide a physical basis for the local gravitational superenergy tensor. Furthermore, our gravitoelectromagnetic deduction of the Bel-Debever-Robinson superenergy tensor permits the identification of the gravitational stress-energy tensor.
Mashhoon, Bahram   +2 more
core   +1 more source

Influence of shear stress applied during flow stoppage and rest period on the mechanical properties of thixotropic suspensions [PDF]

open access: yes, 2008
We study the solid mechanical properties of several thixotropic suspensions as a function of the shear stress history applied during their flow stoppage and their aging in their solid state.
G. Ovarlez   +7 more
core   +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Understanding and Measuring Psychological Stress using Social Media

open access: yes, 2019
A body of literature has demonstrated that users' mental health conditions, such as depression and anxiety, can be predicted from their social media language.
Buffone, Anneke   +4 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The Effect of Socio-economic Status and Related Stress on Physical Health [PDF]

open access: yes, 2010
This review is designed to investigate how socioeconomic status, and the stress related to it, can impact physical health. Much of the research relating to this topic focuses on how low socioeconomic status effects health.
Keene, Makenzie
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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