Results 81 to 90 of about 1,162,787 (260)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement. [PDF]

Neurobiol Pain, 2023
Tanaka K, Kuzumaki N, Hamada Y, Suda Y, Mori T, Nagumo Y, Narita M.   +6 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Psychological peculiarities of the formation and the course of maladaptive states of internship doctors in the aspect of their psychocorrection

Journal of Education, Health and Sport, 2016
Tense working conditions unfavorably affect not only the somatic, but also the mental health of people working in conditions of constant neuropsychic and physical stress.
V. V. Vyun
doaj  

Mental, physical, environmental, and financial challenges of students: do challenges and demographic profile affect students’ perceived hope?

Diversitas Journal
Studying in a university is one of the most difficult stages in an individual’s professional and personal development. During this stage, the individual experiences myriads of challenges including environmental challenges, financial constraints, mental ...
Jomar Aban, Aisha N Sevilleja, Jenilyn A. Asirot, Rachelle D. Ebueza, Sheila E. Calica, Mayeth G. Navasca   +5 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Workplace accidents in Brazil: analysis of physical and psychosocial stress and health-related factors / Acidentes de trabalho no Brasil: análise do estresse físico, psicossocial e fatores relacionados à saúde

RAM. Revista de Administração Mackenzie, 2018
Purpose: To identify the influence of physical and psychosocial stress and health-related factors on the occurrence of work-related accidents, based on the National Health Survey (NHS) conducted in Brazil in 2013, through the execution of a retest in the
Simarly M. Soares, Simone Gelmini, Silvânia S. S. Brandão, June M. C. Silva   +3 more
doaj  

An Analysis of Menstrual Symptoms, Menstrual Attitudes, Physical Stress and Psychological Stress According to the Menstrual Cycle Phase. [PDF]

Iran J Public Health, 2023
Weon HW, Son HK.
europepmc   +1 more source