Results 81 to 90 of about 9,189,271 (249)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Assessment of Fertility in Female Offspring of Stressed Male Rats Treated with Sulpiride
Journal of Mazandaran University of Medical Sciences, 2020 Background and purpose: Chronic stress has detrimental effects on reproductive system. Offspring are likely to be vulnerable to adverse effects from antipsychotic medication and stress transmitted through gonads and gametes.
Shahla Amiri +2 more
doaj
Exploring the Relationship between Childhood Interpersonal Violence, Cortisol Stress Response, and Stress Eating [PDF]
, 2013 Histories of childhood interpersonal violence have been linked to overweight and obesity in adulthood. Despite the fact that victimization experiences are likely to co-occur within individuals, few studies have examined poly-victimization in the context ...
Midei, Aimee J
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Relationship of Physical stress and Hypertension among Cardiovascular Disease Patients
International Journal of Endorsing Health Science Research, 2016 Objective: The aim of the study is to find out amount of physical stress among cardiovascular disease (CVD) patients and its relation with hypertension.
Safdar Ali +6 more
doaj +1 more source
Is there a link between self-perceived stress and physical activity levels in Scottish adolescents? [PDF]
, 2017 Purpose It is becoming more evident that Physical Activity (PA) has a moderating effect on the negative health consequences of excessive psycho-social stress (Stults-Kolehmainen & Sinha, 2014).
Collins, Dave +8 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
, 2020 In the postmenopausal period, women undergo physical and morphological changes that may result in insufficiency and deterioration in physiological functions. It is accepted that oxidative stress is involved in the etiology of postmenopausal changes.
Yener YAZĞAN +3 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source