Results 91 to 100 of about 873,832 (312)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

The possibility of physicalism

open access: yesDementia & Neuropsychologia
Modern science has undermined belief in countless imaginary causalities. What is the nature of the relation between mind and brain? Philosophers have debated the issue for millennia, but it is only in the last twenty years that empirical evidence has ...
Eduardo Giannetti
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

A Surprising Closeness in Latin American Academia: Luther and Certain Neurosciences

open access: yesOpen Theology, 2018
The purpose of this paper is to show a surprising coincidence between Lutheran Protestantism and physicalist neurosciences regarding the negation of free will and how this issue can begin to be studied in Latin American academia.
Martínez-Barrera Jorge
doaj   +1 more source

Mary does not learn anything new: Applying Kim's critique of mental causation to the knowledge argument and the problem of consciousness [PDF]

open access: yes, 2019
Within the discourse surrounding mind-body interaction, mental causation is intimately associated with non-reductive physicalism. However, such a theory holds two opposing views: that all causal properties and relations can ...
Khayat, Adam
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The Hidden Premise in the Causal Argument for Physicalism [PDF]

open access: yes, 2005
The causal argument for physicalism is anayzed and it's key premise--the causal closure of physics--is found wanting. Therefore, a hidden premise must be added to the argument to gain its conclusion, but the hidden premise is indistinguishable from the ...
Bishop, Robert C
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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