Results 111 to 120 of about 12,191 (262)
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
A psique ao encontro da matéria: corpo e pessoa no projeto médico-científico de Nise da Silveira
História, Ciências, Saúde: ManguinhosResumo No início do século XX, a psiquiatria brasileira foi caracterizada por controversos métodos de tratamento, como a eletroconvulsoterapia, as psicocirurgias e o coma insulínico. Em 1946, a médica alagoana Nise da Silveira ocupou a linha de frente na
Felipe Sales Magaldi
doaj +1 more source
Ontological Commitment to the Self as a non-Physical entity in Contemporary Psychology [PDF]
, 2015 No abstract ...
Bleau, Renee, Janssen-Lauret, Frederique
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
How to Achieve the Physicalist Dream Theory of Consciousness: Identity or Grounding? (2020) [PDF]
I argue for three claims. First, there is a strong argument for identity physicalism (Lewis, Sider, Dorr) over dualism. It does achieve the physicalist dream of a maximally simple and uniform view of reality.
Pautz, Adam
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Aging and Cancer, EarlyView.This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Rorty, Dewey, and the issue of metaphysics [PDF]
, 2010 „Rorty, Dewey, and the issue of metaphysics” című írásom keretében először összegzem a Rorty által Deweynak tulajdonított metafizika főbb vonásait, s az a felett gyakorolt, elsősorban a „természet” és a „tapasztalat” közti diszkontinuitást hangsúlyozó ...
Nyírő, Miklós
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