Results 71 to 80 of about 145,897 (292)

Comparison of physician outcome measures and patients' perception of benefits of inpatient neurorehabilitation

, 2002
Rehabilitation aims to reduce the impact of disease, within the limitations imposed by available resources and the underlying disease.1 Measuring rehabilitation is difficult.2 Rating scales of impairment, disability, and handicap are often used but only ...
Hobart, J. C., Thompson, A. J., Hobart, JC, Playford, ED, Edwards, SGM, Thompson, AJ, Edwards, S. G., Playford, E. Diane   +7 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Targeting brain, body and heart for cognitive health and dementia prevention [PDF]

, 2012
This report looks into the current research regarding dementia and Alzheimer\u27s disease prevention and offers ideas for possible future solutions. Prevention of dementia is the ultimate aim of a large, albeit under resourced, international ...
Elodie O'Connor, Maree Farrow
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Serum 25-hydroxyvitamin D and cognitive decline in the very old: The Newcastle 85+ study

, 2015
Background and purpose: Studies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking.
Saxby, B. K., Mathers, John, Wesnes, Keith, Granic, Antoneta, Martin-Ruiz, Carmen, von Zglinicki, Thomas, Davies, Karen, Jagger, Carol, Hill, Thomas H., Collerton, Joanna, Kirkwood, Thomas, Collerton, Daniel   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Quality of life in patients with visual impairment in Ibadan: a clinical study in primary care

, 2014
Kehinde Adigun,1 Tunji S Oluleye,2 Modupe MA Ladipo,1 Samuel Anu Olowookere31Department of Family Medicine; 2Department of Ophthalmology, University College Hospital, Ibadan; 3Department of Community Health, College of Health Sciences, Obafemi Awolowo ...
Ladipo MMA, Oluleye TS, Olowookere SA, Adigun K   +3 more
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ANALYSIS OF FREQUENCY OF VISUAL IMPAIRMENT AND BLINDNESS AMONG OLDER POPULATION [PDF]

, 2019
Introduction: Visual impairment is a major global health problem. The World Health Organization (WHO) estimated that there were 161 million persons worldwide with visual impairment, in the year 2002.
Dr Rukhsana Shamim, Dr Khizra Gull, Dr Noreen Kausar
core   +1 more source