Results 81 to 90 of about 145,897 (292)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Older Adult Driver With Cognitive Impairment

, 2010
Although automobiles remain the transportation of choice for many older adults, late-life cognitive impairment and dementia often impair the ability to drive safely.
David B. Carr, Carr, David B., Brian R. Ott, Ott, Brian R.   +3 more
core   +1 more source

Cognitive testing in older primary care patients: A cluster‐randomized trial

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction This study investigated whether neuropsychological testing in primary care (PC) offices altered physician‐initiated interventions related to cognitive impairment (CI) or slowed the rate of CI progression.
Nicole R. Fowler, Lisa Morrow, Laurel Chiappetta, Beth Snitz, Kimberly Huber, Eric Rodriguez, Judith Saxton   +6 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Clinical profile, prevalence, and burden of chronic spontaneous urticaria in the United States

World Allergy Organization Journal
Background: Data on the prevalence and burden of chronic spontaneous urticaria (CSU) are limited in the United States (US). Objective: To estimate the burden, clinical profile, and prevalence of diagnosed CSU in the United States.
Weily Soong, MD, Dhaval Patil, MS, Jonathan Rodrigues, MD, Ravneet K. Kohli, M. Pharm, Kathryn Krupsky, PhD, Shaloo Gupta, MS, Bridget L. Balkaran, MPH, Maria-Magdalena Balp, MD   +7 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The physical and psychological benefits of martial arts training for individuals with disabilities [PDF]

, 2002
Plan BThe purpose of this study was to determine the physical and emotional benefits of martial arts training for persons with disabilities. Three specific research questions were asked: Does participation in martial arts training lead to a reduction in ...
Martin, Richard A.
core  

Attributes of cognitive impairment in patients on maintenance hemodialysis – A cohort study

BLDE University Journal of Health Sciences
BACKGROUND: Chronic kidney disease patients on hemodialysis have higher cognitive impairment than the normal population due to diminishing renal function.
Geet Gaurav, Deepa Sanjeev Sajjanar, G. V. Naregal, Sanjeev L. Sajjanar   +3 more
doaj   +1 more source

The Importance of Achieving Clear or Almost Clear Skin for Patients: Results from the Nordic Countries of the Global

Acta Dermato-Venereologica, 2018
Psoriasis is a stigmatizing chronic skin condition in which impairment of quality of life is associated with visibility of skin lesions, disease activity and severity. The ultimate goal of treatment is complete clearance of skin symptoms.
Mads Kirchheiner Rasmussen, Martin Enger, Anna-Karin Dahlborn, Siri Juvik, Laura Fagerhed, Rikke Dodge, Charlotta Enerbäck   +6 more
doaj   +1 more source