Results 1 to 10 of about 22,586,824 (312)

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

open access: yesMolecules, 2018
The complex nature of Alzheimer’s disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to potential drug candidates.
Dawid Panek   +8 more
doaj   +1 more source

Synthesis and Characterization of Mechanically Alloyed Nanostructured (Ti,Cr)C Carbide for Cutting Tools Application

open access: yesCrystals, 2022
(Ti,Cr)C is a novel additive for high-performance cermets. In this work, a (Ti0.8Cr0.2)C nanostructured solid solution was synthesized via Mechanical Alloying (MA) from the mixture of of Ti, Cr, and C powders.
Mohsen Mhadhbi, Wojciech Polkowski
doaj   +1 more source

Biphenylalkoxyamine Derivatives–Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity

open access: yesMolecules, 2021
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation.
Dorota Łażewska   +13 more
doaj   +1 more source

A Sensitive Impedimetric Sensor Based on Biosourced Polyphosphine Films for the Detection of Lead Ions

open access: yesChemosensors, 2020
In this work, impedimetric sensors were developed for the detection of the four WFD heavy metals Pb2+, Cd2+, Hg2+ and Ni2+, by the modification of a gold electrode with four partially biosourced polyphosphine polymers.
Taha Chabbah   +10 more
doaj   +1 more source

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2021
The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their
Hyun Myung Lee   +13 more
doaj   +1 more source

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity

open access: yesMolecules, 2020
The inverse correlation observed between Alzheimer’s disease (AD) and cancer has prompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that possess anticancer properties.
Jakub Jończyk   +6 more
doaj   +1 more source

Helosciadium crassipes Koch (Apiaceae) extracts as natural sunscreen and preservative additives

open access: yesNotulae Scientia Biologicae, 2023
Recently, ingredients derived from natural sources have gained increasing interest in the cosmetic field due to their low toxicity. Therefore, this study was designed to explore the cosmetic potential of Helosciadium crassipes Koch (Apiaceae) species ...
El-Hani MAKHLOUFI   +5 more
doaj   +1 more source

Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease

open access: yesMolecules, 2022
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease.
Justyna Godyń   +19 more
doaj   +1 more source

An on-Line NMR Chemical Shift Prediction Platform Based on Density Functional Theory

open access: yesChinese Journal of Magnetic Resonance, 2021
With continuing breakthroughs in computational chemistry theory and substantial improvement of computation hardware performance, great progresses have been made in recent years in first principle-based prediction of 1H and 13C chemical shifts of organic ...
LI Qian, TANG Ya-lin, XIANG Jun-feng
doaj   +1 more source

A Starch-Milk Paste Enables the Incorporation of Ripened Cheese in Novel Fresh Cheese

open access: yesFood Technology and Biotechnology, 2021
Research background. Fresh cheese varieties represent an important share of the whole cheese market. Although with great variability in terms of composition and method of preparation, fresh cheese varieties are bland in flavour and their production ...
Elpiniki Palyvou-Gianna   +3 more
doaj   +1 more source

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