Results 11 to 20 of about 22,586,824 (312)

Untargeted Metabolomics and Physicochemical Analysis Revealed the Quality Formation Mechanism in Fermented Milk Inoculated with Lactobacillus brevis and Kluyveromyces marxianus Isolated from Traditional Fermented Milk [PDF]

Foods, 2023
Traditional fermented milk from the western Sichuan plateau of China has a unique flavor and rich microbial diversity. This study explored the quality formation mechanism in fermented milk inoculated with Lactobacillus brevis NZ4 and Kluyveromyces ...
Xiao-Lin Ao, Yi-Mo Liao, Hai-Yan Kang, Hong-Li Li, Tian He, Li-Kou Zou, Shu-Liang Liu, Shu-Juan Chen, Yong Yang, Xing-Yan Liu   +9 more
doaj   +2 more sources

The effect of ammonia activation on the desalination potential of natural zeolite

Chimica Techno Acta, 2023
Despite the abundance of water bodies on Earth, there is a limited amount of potable water. Therefore, the desalination process is of great interest. Adsorption of the main contaminants of saline water (Na+, K+, Cl– ions) is an alternative process of ...
Aruzhan K. Kenessova, Akmaral B. Rakhym, Bagashar B. Zhaksybay, Gulziya A. Seilkhanova   +3 more
doaj   +1 more source

Analysis of Different Binding Modes for Tiagabine within the GAT-1 Transporter

Biomolecules, 2022
The recently obtained cryo-electron microscopy structure (PDB code: 7SK2) of the human γ-aminobutyric acid transporter type 1 (hGAT-1) in complex with the antiepileptic drug, tiagabine, revealed a rather unexpected binding mode for this inhibitor in an ...
Kamil Łątka, Marek Bajda
doaj   +1 more source

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

Biomolecules, 2021
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life.
Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda   +6 more
doaj   +1 more source

Structure Modeling of the Norepinephrine Transporter

Biomolecules, 2020
The norepinephrine transporter (NET) is one of the monoamine transporters. Its X-ray crystal structure has not been obtained yet. Inhibitors of human NET (hNET) play a major role in the treatment of many central and peripheral nervous system diseases. In
Izabella Góral, Kamil Łątka, Marek Bajda   +2 more
doaj   +1 more source

Physicochemical analysis of nucleobase-metal interactions [PDF]

Nucleic Acids Symposium Series, 2002
It is important to know what kinds of chemical bonds are formed between metal ions and nucleic acids. We have studied metal-nucleobase interactions, by using NMR spectroscopy in solution. For the accurate understanding, we tried measurement at low temperature below -30 degrees C.
Yoshiyuki, Tanaka, Atsushi, Toyozawa, Yoshinori, Kondo   +2 more
openaire   +2 more sources

Physicochemical and microbiological characteristics of fruit-based kombucha [PDF]

, 2023
Kombucha is a fermented drink made out of tea leaves, although recently other alternatives were considered as substitutes, such as fruits. Using different types of fruit could affect the characteristics of fruit-based kombucha.
Cahyadi, A.B., Srianta, I., Zubaidah, E., Tewfik, I.   +3 more
core   +1 more source

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Effective therapy of Alzheimer’s disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease.
Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska   +12 more
doaj   +1 more source

The Analysis of the Physicochemical Properties of Benzocaine Polymorphs [PDF]

Molecules, 2018
The study was a pioneering attempt to assess the influence of the structural polymorphism (forms I, II, III) of benzocaine on its solubility, apparent solubility, and chemical stability, which are vital parameters for preformulation and formulation work.
Magdalena Paczkowska, Gabriela Wiergowska, Andrzej Miklaszewski, Anna Krause, Magdalena Mroczkowka, Przemysław Zalewski, Judyta Cielecka-Piontek   +6 more
openaire   +3 more sources

Guanidines: Synthesis of Novel Histamine H₃R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect

Pharmaceuticals, 2023
This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets.
Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński   +12 more
doaj   +1 more source