Results 11 to 20 of about 586,745 (312)

Biphenylalkoxyamine Derivatives–Histamine H₃ Receptor Ligands with Butyrylcholinesterase Inhibitory Activity

Molecules, 2021
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation.
Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz   +13 more
doaj   +1 more source

In vitro analysis of urinary stone composition in dual-energy computed tomography [PDF]

, 2018
Purpose: Dual energy computed tomography (DECT) is a new method of computed tomography (CT) imaging, allowing the assessment of not only the object's morphology, but also its composition.
Chrzan, Robert, Gawlas, Wojciech, Stępień, Monika   +2 more
core   +1 more source

Self-assembly of Tween 80 micelles as nanocargos for oregano and trans-cinnamaldehyde plant-derived compounds [PDF]

, 2020
The self-assembly of Tween 80 (T80) micelles loaded with plant-based oregano essential oil (OR) and trans-cinnamaldehyde (TCA) was studied. The effect of different factors, including the surfactant to oil ratio, the presence of sodium chloride, thermal ...
Claeys, Myriam, Devlieghere, Frank, Sedaghat Doost, Ali, Stevens, Christian, Van der Meeren, Paul   +4 more
core   +1 more source

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

Molecules, 2016
Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer’s disease. The study describes synthesis and pharmacological evaluation of new compounds designed as dual binding site
Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska   +10 more
doaj   +1 more source

Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer. [PDF]

, 2017
The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes in vitro biochemical analysis challenging.
Bennett, Matthew R, Gomez, Marcella M, Kalvapalle, Prashant, O'Brien-Gilbert, Erin, Perez, Anisha M, Shamoo, Yousif   +5 more
core   +2 more sources

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

Molecules, 2018
The complex nature of Alzheimer’s disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to potential drug candidates.
Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara Malawska   +8 more
doaj   +1 more source

A Sensitive Impedimetric Sensor Based on Biosourced Polyphosphine Films for the Detection of Lead Ions

Chemosensors, 2020
In this work, impedimetric sensors were developed for the detection of the four WFD heavy metals Pb2+, Cd2+, Hg2+ and Ni2+, by the modification of a gold electrode with four partially biosourced polyphosphine polymers.
Taha Chabbah, Houyem Abderrazak, Radhia Souissi, Patrice Saint-Martin, Herve Casabianca, Saber Chatti, Regis Mercier, Ilhem Rassas, Abdelhamid Errachid, Mohamed Hammami, Nicole Jaffrezic-Renault   +10 more
doaj   +1 more source

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their
Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek   +13 more
doaj   +1 more source

Helosciadium crassipes Koch (Apiaceae) extracts as natural sunscreen and preservative additives

Notulae Scientia Biologicae, 2023
Recently, ingredients derived from natural sources have gained increasing interest in the cosmetic field due to their low toxicity. Therefore, this study was designed to explore the cosmetic potential of Helosciadium crassipes Koch (Apiaceae) species ...
El-Hani MAKHLOUFI, Mostefa LEFAHAL, Radia AYAD, Yavuz S. CAKMAK, Gema NIETO, Salah AKKAL   +5 more
doaj   +1 more source

Prediction of peptide and protein propensity for amyloid formation [PDF]

, 2014
Understanding which peptides and proteins have the potential to undergo amyloid formation and what driving forces are responsible for amyloid-like fiber formation and stabilization remains limited.
A Quintas, A Trovato, A Trovato, AC Davison, AC Tsolis, Alexandre Quintas, AM Fernandez-Escamilla, AP Pawar, AV Finkelstein, B Rost, C Nerelius, Carlos Família, CM Dobson, D Eisenberg, David A. Phoenix, DJ Selkoe, DM Fowler, Eugene A. Permyakov, F Chiti, F Chiti, F Sasagawa, GG Tartaglia, GG Tartaglia, H Hu, I Cherny, I Walsh, IV Baskakov, J Palau, J Tian, JC Rochet, JD Sipe, JM Zimmerman, JW Kelly, JW Kelly, K Rajagopal, KF DuBay, KK Frousios, KT O’Neil, L Goldschmidt, LO Jimenez, M Belli, M Emily, M Hollander, M Kuhn, M López de la Paz, M Oliveberg, M Stefani, M Sunde, M Sunde, M Zamani, MB Kursa, MJ Thompson, MT Pastor, N Becker, N Qian, O Conchillo-Solé, PK Teng, PY Chou, RS Harrison, S Idicula-thomas, S Kawashima, S Kawashima, S Maurer-Stroh, S Ventura, S Yoon, S Yoon, Sarah R. Dennison, SJ Hamodrakas, SJ Hamodrakas, SK Maji, SO Garbuzynskiy, T Hothorn, T Hothorn, T Hothorn, T Scheibel, TPJ Knowles, VS Mathura, WH DePas, WT Astbury, Y Kallberg, Ž Eva   +80 more
core   +5 more sources