Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling
Molecular Metabolism, 2017 Objective: In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. In mice with diet-induced obesity (DIO)
Joseph Tam +7 more
doaj +1 more source
Anatomic and Physiologic Basis for Gaze Stability
, 2022 Diagram describing the anatomic and physiologic basis of gaze ...
Ariel Winnick and Meagan Seay, DO
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Physiology in Perspective: The Importance of Integrative Physiology [PDF]
Physiology, 2017 “The doctor of the future will give no medicine, but will interest his (her) patients in the care of the human frame, in diet, and in the cause and prevention of disease.” This comment, attributed to Thomas Edison, presaged the modern concepts of managed health care, health ...
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Synthetic cannabinoids induce acute lung inflammation via cannabinoid receptor 1 activation
ERJ Open Research, 2020 Charles N. Zawatsky +2 more
doaj +1 more source
Levels and patterns of physical activity in children and adolescents with Type 1 diabetes and associated metabolic and physiologic health outcomes [PDF]
, 2010 Background: The present study objectively assessed physical activity (PA) levels and patterns in children and adolescents with type 1 diabetes and compared the metabolic and physiologic health profiles of those achieving and those not achieving the ...
Roche, D.M., Edmunds, S., Stratton, G.
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Physiology in Perspective: The Value of Integrative Physiology [PDF]
Physiology, 2017 Almost a year ago, I gained a close and personal appreciation for the value gained from an understanding of integrative physiology. Suddenly one morning, while on vacation, I was struck by a massive pulmonary embolism and experienced first hand the importance of the interaction between the ...
openaire +2 more sources
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Cardiovascular Risk Factors and Specific Coronary Artery Calcification in Postmenopausal Women
Journal of Tehran University Heart Center, 2009 Background: Myocardial infarctions at different locations have been related to different sets of risk factors. This study was designed to examine the association between cardiovascular risk factors and specific coronary artery calcification (CAC ...
Siamak Sabour +6 more
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